Arimoclomol (Synonyms: BRX-220 free base)

Cat. No.: HY-106443: FAQs
Data Sheet Handling Instructions

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.

For research use only. We do not sell to patients.

Arimoclomol Chemical Structure

CAS No. : 289893-25-0

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This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Arimoclomol:

Arimoclomol maleate

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Arimoclomol maleate In-stock
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2 Publications Citing Use of MCE Arimoclomol

View All HSP Isoform Specific Products:

View All Isoforms

HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

Biological Activity
Purity & Documentation
References
Customer Review

Description

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP)^[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system^[2].

IC₅₀ & Target^[1]

HSP

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 240 to 270 g^[1]
Dosage:	20 mg/kg
Administration:	Administered intragastrically, for 5 days
Result:	Had a protective effect against CCK-induced acute pancreatitis.

Clinical Trial

Molecular Weight

313.78

Formula

C₁₄H₂₀ClN₃O₃

CAS No.

289893-25-0

SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[[email protected]](O)CN2CCCCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]

[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Arimoclomol289893-25-0BRX-220BRX220BRX 220HSPHeat shock proteinsco-inducermotorneuronsproteinaggregationclearancemisfoldedassembliesproteasomeubiquitinsystemInhibitorinhibitorinhibit

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