1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Arimoclomol

Arimoclomol (Synonyms: BRX-220 free base)

Cat. No.: HY-106443
Handling Instructions

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.

For research use only. We do not sell to patients.

Arimoclomol Chemical Structure

Arimoclomol Chemical Structure

CAS No. : 289893-25-0

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Description

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].

IC50 & Target[1]

HSP

 

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 240 to 270 g[1]
Dosage: 20 mg/kg
Administration: Administered intragastrically, for 5 days
Result: Had a protective effect against CCK-induced acute pancreatitis.
Clinical Trial
Molecular Weight

313.78

Formula

C₁₄H₂₀ClN₃O₃

CAS No.

289893-25-0

SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[[email protected]](O)CN2CCCCC2

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ArimoclomolBRX-220BRX220BRX 220HSPHeat shock proteinsco-inducermotorneuronsproteinaggregationclearancemisfoldedassembliesproteasomeubiquitinsystemInhibitorinhibitorinhibit

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Arimoclomol
Cat. No.:
HY-106443
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