2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Arimoclomol

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Arimoclomol maleate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Arimoclomol Chemical Structure

Arimoclomol Chemical Structure

CAS No. : 289893-25-0

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Arimoclomol Related Antibodies

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Description

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].

IC50 & Target[1]

HSP

 

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 240 to 270 g[1]
Dosage: 20 mg/kg
Administration: Administered intragastrically, for 5 days
Result: Had a protective effect against CCK-induced acute pancreatitis.
Clinical Trial
Molecular Weight

313.78

Formula

C14H20ClN3O3
CAS No.
SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Arimoclomol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arimoclomol289893-25-0BRX-220BRX220BRX 220HSPHeat shock proteinsco-inducermotorneuronsproteinaggregationclearancemisfoldedassembliesproteasomeubiquitinsystemInhibitorinhibitorinhibit

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