2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Arimoclomol

Arimoclomol  (Synonyms: BRX-220 free base)

Cat. No.: HY-106443 Purity: 99.83%
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Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann–Pick disease type C. Arimoclomol can cross the blood-brain barrier and can be used in research on Niemann-Pick disease type C.

For research use only. We do not sell to patients.

CAS No. : 289893-25-0

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Arimoclomol:

Arimoclomol Related Antibodies

Top Publications Citing Use of Products

    Arimoclomol purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 May 16;25(10):5417.  [Abstract]

    Representative western blotting showing the effect of Arimoclomol maleate (Ari: 300 μM) treatments on protein expression in PS1 (PS1KO) and PS2 KO (PS2KO) mouse embryonic fibroblasts (MEFs).

    Arimoclomol purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2019 Nov;188:107792.  [Abstract]

    Western blot was used to detect the expression of HSP70 in ARPE-19 cells stimulated by Arimoclomol maleate (10 μM) for 24 h.

    Arimoclomol purchased from MedChemExpress. Usage Cited in: Exp Eye Res. 2019 Nov;188:107792.  [Abstract]

    ARPE-19 cells were simultaneously treated with 4-HNE and Arimoclomol (10 μM) for 24 h, then IL-1β levels in supernatant of ARPE-19 cells were detected by corresponding ELISA kit.

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    Description

    Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann–Pick disease type C. Arimoclomol can cross the blood-brain barrier and can be used in research on Niemann-Pick disease type C[1][2][3].

    IC50 & Target[1]

    HSP

     

    In Vivo

    Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].
    In the SOD1-G93A mouse model of amyotrophic lateral sclerosis, arimoclomol can delay muscle denervation[2].
    Arimoclomol has been used in preclinical studies for neurodegenerative lysosomal storage diseases, such as Niemann-Pick disease type C (NPC), and has shown improvement in the core pathological lesions of central nervous system (CNS) involvement in Gaucher disease (GD2, GD3)[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats weighing 240 to 270 g[1]
    Dosage: 20 mg/kg
    Administration: Administered intragastrically, for 5 days
    Result: Had a protective effect against CCK-induced acute pancreatitis.
    Clinical Trial
    Molecular Weight

    313.78

    Formula

    C14H20ClN3O3
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (79.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1869 mL 15.9347 mL 31.8695 mL
    5 mM 0.6374 mL 3.1869 mL 6.3739 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.83%

    SDS (393 KB)

    COA (244 KB) HNMR (480 KB) LCMS (97 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.1869 mL 15.9347 mL 31.8695 mL 79.6737 mL
    5 mM 0.6374 mL 3.1869 mL 6.3739 mL 15.9347 mL
    10 mM 0.3187 mL 1.5935 mL 3.1869 mL 7.9674 mL
    15 mM 0.2125 mL 1.0623 mL 2.1246 mL 5.3116 mL
    20 mM 0.1593 mL 0.7967 mL 1.5935 mL 3.9837 mL
    25 mM 0.1275 mL 0.6374 mL 1.2748 mL 3.1869 mL
    30 mM 0.1062 mL 0.5312 mL 1.0623 mL 2.6558 mL
    40 mM 0.0797 mL 0.3984 mL 0.7967 mL 1.9918 mL
    50 mM 0.0637 mL 0.3187 mL 0.6374 mL 1.5935 mL
    60 mM 0.0531 mL 0.2656 mL 0.5312 mL 1.3279 mL
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    Arimoclomol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Arimoclomol289893-25-0BRX-220BRX220BRX 220HSPHeat shock proteinsco-inducermotorneuronsproteinaggregationclearancemisfoldedassembliesproteasomeubiquitinsystemInhibitorinhibitorinhibit

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