1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Arimoclomol

Arimoclomol (Synonyms: BRX-220 free base)

Cat. No.: HY-106443
Handling Instructions

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP).

For research use only. We do not sell to patients.

Arimoclomol Chemical Structure

Arimoclomol Chemical Structure

CAS No. : 289893-25-0

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Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP).

IC50 & Target[1]



In Vivo

The HSP coinducer Arimoclomol (BRX-220), administered for 5 d, has a protective effect against CCK-induced acute pancreatitis. Repeated CCK treatment results in the typical laboratory and morphological changes of experimentally induced pancreatitis. The pancreatic levels of HSP60 and HSP72 are significantly increased in the animals treated with Arimoclomol [1]. Arimoclomol is a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease[2].

Molecular Weight







Cl/C(C(C=CC=1)=CN1=O)=N\OC[[email protected]](O)CN2CCCCC2


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

Male Wistar rats weighing 240-270 g are used. The animals are kept at a constant room temperature of 25°C with a 12 h light-dark cycle, and are allowed free access to water and standard laboratory chow. The rats are fasted 18 h before the end of the experiment. In group B (n=6), 20 mg/kg Arimoclomol (BRX-220) is administered intragastrically, followed by 75 μg/kg CCK subcutaneously three times, after 1, 3, and 5 h. This whole procedure is repeated for 5 d. The animals in group AB (n=6) receive physiological saline intragastrically instead of Arimoclomol, but otherwise the protocol is the same as in group B. The animals are sacrificed by exsanguination through the abdominal aorta 12 h after the last CCK injection. Three untreated rats (A) are killed for HSP60 and 72 determinations. The pancreas is quickly removed, cleaned from fat and lymph nodes, weighed, and frozen at -70°C until use[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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ArimoclomolBRX-220BRX220BRX 220HSPHeat shock proteinsInhibitorinhibitorinhibit

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