289893-26-1
Chemical Structure
Arimoclomol maleate
Synonym(s): BRX-220
- CAS No.: 289893-26-1
- Formula:C18H24ClN3O7
- Molecular Weight:429.85
IUPAC Name: (R,Z)-3-(chloro((2-hydroxy-3-(piperidin-1-yl)propoxy)imino)methyl)pyridine 1-oxide maleate
InChIKey: OHUSJUJCPWMZKR-GARNONDBSA-N
SMILES: Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2.OC(/C=C\C(O)=O)=O
Biological Activity: Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2].Arimoclomol maleate can be used for the study of Niemann–Pick disease type C.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Arimoclomol maleate | 99.95% | Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol maleate can be used for the study of Niemann–Pick disease type C. | ||||||||||||||||||||
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Arimoclomol maleate (Standard) | ≥98% | Arimoclomol maleate (Standard) is the analytical standard of Arimoclomol maleate (HY-106443A). This product is intended for research and analytical applications. Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol maleate can be used for the study of Niemann–Pick disease type C. | ||||||||||||||||||||
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References
- [1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]
- [2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]
