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Cat. No.: HY-142980

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DOPG

(Synonyms: Dioleoylphosphatidylglycerol)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion.

For research use only. We do not sell to patients.

CAS No.: 62700-69-0
Formula: C₄₂H₇₉O₁₀P
Molecular Weight:775.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DOPG Chemical Structure

CAS No.: 62700-69-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

DOPG (10 µg/mL) inhibits the production of macrophage inflammatory mediators induced by heat shock protein B4 via activation of Toll-like receptor 2^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 62700-69-0
Molecular Weight 775.04
Formula C₄₂H₇₉O₁₀P
SMILES

OCC(O)COP(OC[C@@H](COC(CCCCCCC/C=C\CCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O
Synonyms

Dioleoylphosphatidylglycerol
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Biomaterials

AI agent-based discovery of D-enantiomeric antimicrobial peptides against multidrug-resistant bacterial infection. [Abstract]

2026 Jun:329:123927. PMID: 41443039
ACS Appl Mater Interfaces

Self-Assembling Lauroylated Antimicrobial Peptide with Superior Antimicrobial Activity, Stability, and Selectivity. [Abstract]

2025 Mar 5;17(9):13646-13659. PMID: 39964258
J Photochem Photobiol B

Disinfection mechanisms of gram-negative and gram-positive bacteria through multi-target damage under UV-C light at 222 and 254 nm. [Abstract]

2026 Feb:275:113362. PMID: 41520611

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dargel C, et al. Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules. 2021;26(16):4959. Published 2021 Aug 16. [Content Brief]

[2]. Chang L, et al. Low-dose dioleoylphosphatidylglycerol (DOPG) inhibits heat shock protein B4 (HSPB4)-induced activation of toll-like receptor 2 (TLR2) in a reporter cell line. Investigative Ophthalmology & Visual Science, 2020, 61(7): 357-357.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Publications (3)
Purity & Documentation
References

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DOPG

Publications Citing Use of MedChemExpress (MCE) DOPG