62700-69-0
Chemical Structure
DOPG
Synonym(s): Dioleoylphosphatidylglycerol
- CAS No.: 62700-69-0
- Formula:C42H79O10P
- Molecular Weight:775.04
IUPAC Name: 4-(bis(ethyl-d5)amino)but-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate hydrochloride
InChIKey: DSNRWDQKZIEDDB-GCMPNPAFSA-N
SMILES: OCC(O)COP(OC[C@@H](COC(CCCCCCC/C=C\CCCCCCCC)=O)OC(CCCCCCC/C=C\CCCCCCCC)=O)(O)=O
Biological Activity: DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion[1][2].
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DOPG | DOPG (Dioleoylphosphatidylglycerol) is a negatively charged phosphatidylglycerol phospholipid. DOPG is abundant in prokaryotic cell membranes and mitochondria, and has a low phase transition temperature and a tendency to form stable vesicles. DOPG inhibits the production of inflammatory mediators in macrophages in response to heat shock protein B4 (HSPB4)-activated toll-like receptor 2 (TLR2). DOPG is applicable to studies of membrane biology, drug-membrane interactions (especially in systems targeting negatively charged membranes), construction of drug delivery carriers, as well as research on sterile corneal inflammation and wound healing promotion. | |||||||||||||||||||||
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References
- [1]. Dargel C, et al. Stable DOPG/Glycyrrhizin Vesicles with a Wide Range of Mixing Ratios: Structure and Stability as Seen by Scattering Experiments and Cryo-TEM. Molecules. 2021;26(16):4959. Published 2021 Aug 16. [Content Brief]
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[2]. Chang L, et al. Low-dose dioleoylphosphatidylglycerol (DOPG) inhibits heat shock protein B4 (HSPB4)-induced activation of toll-like receptor 2 (TLR2) in a reporter cell line. Investigative Ophthalmology & Visual Science, 2020, 61(7): 357-357.
