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  4. Ponceau 4R (85%)

Ponceau 4R (85%)  (Synonyms: Acid Red 18 (85%); New Coccine (85%))

Cat. No.: HY-D0193A Purity: 85.0%
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Ponceau 4R (85%) (Acid Red 18 (85%); New Coccine (85%)) is an orally active synthetic food colorant and a HSA-binding aggregator. Ponceau 4R (85%) binds to HSA, inducing its partial unfolding, conformational changes and aggregation. Ponceau 4R (85%) serves as a food colorant and can be used in research on diseases including type Ⅱ diabetes, Parkinson's disease, Huntington's disease and spongiform encephalopathy.

For research use only. We do not sell to patients.

Ponceau 4R (85%)

Ponceau 4R (85%) Chemical Structure

CAS No. : 2611-82-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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Ponceau 4R (85%) Related Antibodies

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Description

Ponceau 4R (85%) (Acid Red 18 (85%); New Coccine (85%)) is an orally active synthetic food colorant and a HSA-binding aggregator. Ponceau 4R (85%) binds to HSA, inducing its partial unfolding, conformational changes and aggregation. Ponceau 4R (85%) serves as a food colorant and can be used in research on diseases including type Ⅱ diabetes, Parkinson's disease, Huntington's disease and spongiform encephalopathy[1][2][3].

In Vitro

Ponceau 4R (5-30 µM) binds to a single site on human serum albumin at pH 2.0 via static fluorescence quenching, with a binding constant of 1.43 × 105 M-1[1].
Ponceau 4R (80-200 µM; overnight) induces aggregation of human serum albumin at pH 2.0, as measured by increased Rayleigh light scattering at 650 nm[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ponceau 4R (85%) Related Antibodies
In Vivo

Ponceau 4R (205 mg/kg; p.o.; daily) causes cognitive deficits in first-generation male rats, while its effects on female rats are inconsistent[2].
Ponceau 4R causes a significant increase in nuclear DNA migration in multiple organs of mice, with no associated cytotoxicity[2].
Ponceau 4R (2000 mg/kg; p.o.; single administration) exhibits low acute oral toxicity in male *Mus musculus* (house mouse), with an LD50 greater than 2000 mg/kg bw[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified (male and female)[2]
Dosage: 205 mg/kg
Administration: p.o.; daily
Result: Recorded cognitive deficits in first-generation male rats at the tested dose.
Observed no consistent deficits in female rats.
Animal Model: unspecified (male)[3]
Dosage: 2000 mg/kg bw
Administration: p.o.; single dose
Result: Observed no mortality following single-dose administration.
Determined median lethal dose (LD50) to be greater than 2000 mg/kg bw.
Molecular Weight

604.47

Formula

C20H11N2Na3O10S3
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

O=S(C1=C2C(/N=N/C3=C4C=CC=CC4=C(S(=O)(O[Na])=O)C=C3)=C(O)C=CC2=CC(S(=O)(O[Na])=O)=C1)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (165.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6543 mL 8.2717 mL 16.5434 mL
5 mM 0.3309 mL 1.6543 mL 3.3087 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 85.0%

SDS (396 KB)

COA (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.6543 mL 8.2717 mL 16.5434 mL 41.3585 mL
5 mM 0.3309 mL 1.6543 mL 3.3087 mL 8.2717 mL
10 mM 0.1654 mL 0.8272 mL 1.6543 mL 4.1359 mL
15 mM 0.1103 mL 0.5514 mL 1.1029 mL 2.7572 mL
20 mM 0.0827 mL 0.4136 mL 0.8272 mL 2.0679 mL
25 mM 0.0662 mL 0.3309 mL 0.6617 mL 1.6543 mL
30 mM 0.0551 mL 0.2757 mL 0.5514 mL 1.3786 mL
40 mM 0.0414 mL 0.2068 mL 0.4136 mL 1.0340 mL
50 mM 0.0331 mL 0.1654 mL 0.3309 mL 0.8272 mL
60 mM 0.0276 mL 0.1379 mL 0.2757 mL 0.6893 mL
80 mM 0.0207 mL 0.1034 mL 0.2068 mL 0.5170 mL
100 mM 0.0165 mL 0.0827 mL 0.1654 mL 0.4136 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ponceau 4R (85%) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponceau 4R (85%)2611-82-7Acid Red 18 (85%) New Coccine (85%)Drug DerivativeEnvironmental PollutantsDrug derivativeEnvironmental Contaminantspolypeptide backboneshuman serum albuminCongo reddomain IIAaromatic amino acid residuesfreshwater fishα-helical structurecross-β conformationmiceratsfood coloranttype Ⅱ diabetesParkinson's diseaseHuntington's diseasespongiform encephalopathyInhibitorinhibitorinhibit

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