2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. NXP800

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research.

For research use only. We do not sell to patients.

NXP800 Chemical Structure

NXP800 Chemical Structure

CAS No. : 1693734-80-3

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 426 In-stock
Solution
10 mM * 1 mL in DMSO USD 426 In-stock
Solid
5 mg USD 340 In-stock
10 mg USD 550 In-stock
25 mg USD 1100 In-stock
50 mg USD 1750 In-stock
100 mg USD 2800 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

NXP800 Related Antibodies

Top Publications Citing Use of Products

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has the potential for cancer research[1][2].

IC50 & Target[1]

HSF1

 

In Vitro

NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NXP800 Related Antibodies
In Vivo

NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control[2].

Pharmacokinetic Analysis[2]

Species Route Dose (mg/kg) Tmax (h) AUClast (ng·h/mL) Cltb (mL/min/kg) t1/2 (h) F (%) AUCu0-t (h·nM) Free Cav0-24h (nM) Clu (mL/min/kg)
mouse po/iv 5/5 2.0 6000 (7800-4600) (po) 10 (10-9.7) (iv) 4.0 42 (po) 72 3.3 830 (iv)
rat po/iv 5/1 6.0 2600 (po) 24 (iv) 3.1 45 (po) 86 3.7 730 (iv)
dog po/iv 2.5/0.5 2.0 250 (po) 21 (iv) 1.4 9.1 (po) 35 1.9 150 (iv)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

569.63

Formula

C32H32FN5O4
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(C1=CC=C2OCCOC2=C1)NC3=CC=C(C(NC(C4=CC5=C(N=C(CN6CCN(CC6)CC)C=C5)C=C4)=O)=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (175.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7555 mL 8.7776 mL 17.5553 mL
5 mM 0.3511 mL 1.7555 mL 3.5111 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.79%

COA (244 KB) HNMR (275 KB) LCMS (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7555 mL 8.7776 mL 17.5553 mL 43.8881 mL
5 mM 0.3511 mL 1.7555 mL 3.5111 mL 8.7776 mL
10 mM 0.1756 mL 0.8778 mL 1.7555 mL 4.3888 mL
15 mM 0.1170 mL 0.5852 mL 1.1704 mL 2.9259 mL
20 mM 0.0878 mL 0.4389 mL 0.8778 mL 2.1944 mL
25 mM 0.0702 mL 0.3511 mL 0.7022 mL 1.7555 mL
30 mM 0.0585 mL 0.2926 mL 0.5852 mL 1.4629 mL
40 mM 0.0439 mL 0.2194 mL 0.4389 mL 1.0972 mL
50 mM 0.0351 mL 0.1756 mL 0.3511 mL 0.8778 mL
60 mM 0.0293 mL 0.1463 mL 0.2926 mL 0.7315 mL
80 mM 0.0219 mL 0.1097 mL 0.2194 mL 0.5486 mL
100 mM 0.0176 mL 0.0878 mL 0.1756 mL 0.4389 mL
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NXP800 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NXP8001693734-80-3CCT361814NXP 800NXP-800CCT 361814CCT-361814HSPHeat shock proteinsInhibitorinhibitorinhibit

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