2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Cucurbitacin D

Cucurbitacin D 

Cat. No.: HY-N1986 Purity: 99.91%
COA Handling Instructions

Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity.

For research use only. We do not sell to patients.

Cucurbitacin D Chemical Structure

Cucurbitacin D Chemical Structure

CAS No. : 3877-86-9

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 386 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 386 In-stock
Solid
1 mg USD 85 In-stock
5 mg USD 340 In-stock
10 mg USD 580 In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Cucurbitacin D Related Antibodies

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Description

Cucurbitacin D is an active component in Trichosanthes kirilowii, disrupts interactions between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D prevents Hsp90 client (Her2, Raf, Cdk6, pAkt) maturation without induction of the heat shock response. Anti-cancer activity[1].

IC50 & Target[1]

HSP90

 

Molecular Weight

516.67

Appearance

Solid

Formula

C30H44O7
CAS No.
SMILES

C[C@@]([C@@](CC=C(C(C)1C)[C@@]2([H])C[C@H](O)C1=O)([H])[C@@]2(C)C3=O)(C[C@@H](O)[C@]4([H])[C@@](C)(O)C(/C=C/C(C)(O)C)=O)[C@@]4(C3)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 110 mg/mL (212.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9355 mL 9.6774 mL 19.3547 mL
5 mM 0.3871 mL 1.9355 mL 3.8709 mL
10 mM 0.1935 mL 0.9677 mL 1.9355 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.75 mg/mL (5.32 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.32 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.91%

COA (254 KB) HNMR (227 KB) RP-HPLC (364 KB)

Handling Instructions (2659 KB)
References
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Cucurbitacin D Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Cucurbitacin D3877-86-9HSPHeat shock proteinsInhibitorinhibitorinhibit

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