Cytotoxic cucurbitacin constituents from Sloanea zuliaensis

  • J Nat Prod. 2003 Nov;66(11):1515-6. doi: 10.1021/np0303106.
Nelson Rodriguez  1 ,  Yelkaira Vasquez ,  Ahmed A Hussein ,  Phyllis D Coley ,  Pablo N Solis ,  Mahabir P Gupta
Affiliations
  • 1. Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panamá, República de Panamá.
PMID: 14640532 DOI: 10.1021/np0303106
Abstract

A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human Cancer cell lines.