1. MAPK/ERK Pathway
  2. p38 MAPK
  3. SD-169

SD-169 

Cat. No.: HY-W015445
Handling Instructions

SD-169 is an orally active ATP competitive inhibitor of MAPK p38α, with an IC50 of 3.2 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation.

For research use only. We do not sell to patients.

SD-169 Chemical Structure

SD-169 Chemical Structure

CAS No. : 1670-87-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
50 mg USD 150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SD-169 is an orally active ATP competitive inhibitor of MAPK p38α, with an IC50 of 3.2 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].

IC50 & Target[1]

p38α MAPK

3.2 nM (IC50)

In Vitro

SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1].
SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1].

Molecular Weight

160.18

Formula

C₉H₈N₂O

CAS No.

1670-87-7

SMILES

O=C(C1=CC2=C(NC=C2)C=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

SD-169SD169SD 169p38 MAPKmitogen-activatedproteinkinasesMAPKp38αheatshockproteinsHSPsdiabeteInhibitorinhibitorinhibit

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