2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP90-IN-18

HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation.

For research use only. We do not sell to patients.

HSP90-IN-18

HSP90-IN-18 Chemical Structure

CAS No. : 2927442-45-1

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HSP90-IN-18 Related Antibodies

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Description

HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1].

IC50 & Target

IC50: 0.39 μM (Hsp90); 17.65 μM (MCF-7); 20.03 μM (SW480); ＞40 μM (A549); 3.69 μM (HL60); 11.92 μM (SMMC-7721)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 40 μM
Compound: 29
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
HL-60 IC50
3.69 μM
Compound: 29
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
MCF7 IC50
17.65 μM
Compound: 29
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
SMMC-7721 IC50
11.92 μM
Compound: 29
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
SW480 IC50
20.03 μM
Compound: 29
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 36274275]
In Vitro

HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM[1].
HSP90-IN-18 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) has antiproliferative activity against MCF-7, SW480, A549, HL60 and SMMC-7721 with IC50 values of 17.65 μM, 20.03 μM, ＞40 μM, 3.69 μM and 11.92 μM, respectively[1].
HSP90-IN-18 (0, 1, 5, 10, 20 μM; 12-16 h) promotes HL-60 cell apoptosis by mitochondrial-mediated apoptosis pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSP90-IN-18 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HL-60, A549, SMMC7721, MCF-7 and SW480 cell lines
Concentration: 40, 8, 1.6, 0.32, 0.064 μM
Incubation Time: 48 h
Result: Showed much better anti-proliferation activities in five cancer cell lines, especially against human leukocyte cell line.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 0, 1, 5, 10, 20 μM
Incubation Time: 12-16 h
Result: Promoted the apoptosis of HL-60 cells.

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 0, 1, 5, 10 μM
Incubation Time: 24 h
Result: Showed the expression of Bcl2 was significantly reduced, while Bax was increased.
In Vivo

HSP90-IN-18 (i.p.; 100 mg/kg; for 14 days) suppresses tumor growth in the H22 tumor-bearing mice model and revealed low acute toxicity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming Mice (female; 18–20g)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal administration for 14 days
Result: Showed normal behavior and feeding habits without any signs of toxicity and demonstrated low acute toxicity (LD50 > 500 mg/kg).
Molecular Weight

400.53

Formula

C25H33FO3
CAS No.
SMILES

C/C(C)=C\CC[C@]1(CC=C(C2=C([C@@H]1/C=C/OC(/C=C(C)/C)=O)C=C(O2)C)CF)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP90-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-182927442-45-1HSPApoptosisHeat shock proteinsheat shock protein 90 (Hsp90)viral infectionneurodegenerative diseaseinflammationInhibitorinhibitorinhibit

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