2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. HSP90-IN-18

HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation.

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HSP90-IN-18 Chemical Structure

HSP90-IN-18 Chemical Structure

CAS No. : 2927442-45-1

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HSP90-IN-18 Related Antibodies

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Description

HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1].

IC50 & Target

IC50: 0.39 μM (Hsp90); 17.65 μM (MCF-7); 20.03 μM (SW480); ＞40 μM (A549); 3.69 μM (HL60); 11.92 μM (SMMC-7721)[1]
In Vitro

HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM[1].
HSP90-IN-18 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) has antiproliferative activity against MCF-7, SW480, A549, HL60 and SMMC-7721 with IC50 values of 17.65 μM, 20.03 μM, ＞40 μM, 3.69 μM and 11.92 μM, respectively[1].
HSP90-IN-18 (0, 1, 5, 10, 20 μM; 12-16 h) promotes HL-60 cell apoptosis by mitochondrial-mediated apoptosis pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSP90-IN-18 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HL-60, A549, SMMC7721, MCF-7 and SW480 cell lines
Concentration: 40, 8, 1.6, 0.32, 0.064 μM
Incubation Time: 48 h
Result: Showed much better anti-proliferation activities in five cancer cell lines, especially against human leukocyte cell line.

Apoptosis Analysis[1]

Cell Line: HL-60 cells
Concentration: 0, 1, 5, 10, 20 μM
Incubation Time: 12-16 h
Result: Promoted the apoptosis of HL-60 cells.

Western Blot Analysis[1]

Cell Line: HL-60 cells
Concentration: 0, 1, 5, 10 μM
Incubation Time: 24 h
Result: Showed the expression of Bcl2 was significantly reduced, while Bax was increased.
In Vivo

HSP90-IN-18 (i.p.; 100 mg/kg; for 14 days) suppresses tumor growth in the H22 tumor-bearing mice model and revealed low acute toxicity in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming Mice (female; 18–20g)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal administration for 14 days
Result: Showed normal behavior and feeding habits without any signs of toxicity and demonstrated low acute toxicity (LD50 > 500 mg/kg).
Molecular Weight

400.53

Formula

C25H33FO3
CAS No.
SMILES

C/C(C)=C\CC[C@]1(CC=C(C2=C([C@@H]1/C=C/OC(/C=C(C)/C)=O)C=C(O2)C)CF)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP90-IN-18 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP90-IN-182927442-45-1HSPApoptosisHeat shock proteinsheat shock protein 90 (Hsp90)viral infectionneurodegenerative diseaseinflammationInhibitorinhibitorinhibit

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