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Cat. No.: HY-152027

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HSP90-IN-18

HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation.

For research use only. We do not sell to patients.

CAS No.: 2927442-45-1
Formula: C₂₅H₃₃FO₃
Molecular Weight:400.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

HSP90-IN-18 Chemical Structure

CAS No.: 2927442-45-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.39 μM (Hsp90); 17.65 μM (MCF-7); 20.03 μM (SW480); ＞40 μM (A549); 3.69 μM (HL60); 11.92 μM (SMMC-7721)^[1]

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>40 μM Compound: 29	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36274275]
HL-60	IC₅₀	3.69 μM Compound: 29	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36274275]
MCF7	IC₅₀	17.65 μM Compound: 29	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36274275]
SMMC-7721	IC₅₀	11.92 μM Compound: 29	Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36274275]
SW480	IC₅₀	20.03 μM Compound: 29	Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 36274275]

In Vitro

HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC₅₀ value of 0.39 μM^[1].
HSP90-IN-18 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) has antiproliferative activity against MCF-7, SW480, A549, HL60 and SMMC-7721 with IC₅₀ values of 17.65 μM, 20.03 μM, ＞40 μM, 3.69 μM and 11.92 μM, respectively^[1].
HSP90-IN-18 (0, 1, 5, 10, 20 μM; 12-16 h) promotes HL-60 cell apoptosis by mitochondrial-mediated apoptosis pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HL-60, A549, SMMC7721, MCF-7 and SW480 cell lines
Concentration:

40, 8, 1.6, 0.32, 0.064 μM
Incubation Time:

48 h
Result:

Showed much better anti-proliferation activities in five cancer cell lines, especially against human leukocyte cell line.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

0, 1, 5, 10, 20 μM
Incubation Time:

12-16 h
Result:

Promoted the apoptosis of HL-60 cells.

Western Blot Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

0, 1, 5, 10 μM
Incubation Time:

24 h
Result:

Showed the expression of Bcl2 was significantly reduced, while Bax was increased.

In Vivo

HSP90-IN-18 (i.p.; 100 mg/kg; for 14 days) suppresses tumor growth in the H22 tumor-bearing mice model and revealed low acute toxicity in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming Mice (female; 18–20g)^[1]
Dosage:

100 mg/kg
Administration:

Intraperitoneal administration for 14 days
Result:

Showed normal behavior and feeding habits without any signs of toxicity and demonstrated low acute toxicity (LD₅₀ > 500 mg/kg).

Chemical Information

CAS No. 2927442-45-1
Molecular Weight 400.53
Formula C₂₅H₃₃FO₃
SMILES

C/C(C)=C\CC[C@]1(CC=C(C2=C([C@@H]1/C=C/OC(/C=C(C)/C)=O)C=C(O2)C)CF)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Meng Li, et al. Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives. Eur J Med Chem. 2022 Dec 15;244:114844. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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HSP90-IN-18

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HSP90-IN-18 Related Classifications

HY-152027 Related Classifications