1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. Cemdomespib

Cemdomespib (Synonyms: KU-596)

Cat. No.: HY-145559
Handling Instructions

Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response.

For research use only. We do not sell to patients.

Cemdomespib Chemical Structure

Cemdomespib Chemical Structure

CAS No. : 1450642-92-8

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Description

Cemdomespib (KU-596) is a highly bioavailable second-generation Hsp90 modulator. Cemdomespib has shown efficacy in improving sensory deficits in models of diabetic peripheral neuropathy. Cemdomespib induces Hsp70 levels and manifest neuroprotective activity through induction of the heat shock response[1][2][3].

IC50 & Target[1]

HSP90

 

In Vivo

After 8 weeks of diabetes, Cemdomespib (KU-596; 2, 10, or 20 mg/kg ; i.p.; administered for 6 weeks via a once per week) dose-dependently reverses the pre-existing psychosensory deficits. Cemdomespib also dose-dependently prevents the diabetes-induced deficits in motor (MNCV) and sensory (SNCV) nerve conduction velocities[1].
Cemdomespib (20 mg/kg; oral gavage once per week for 4 weeks) significantly reverses the sensory hypoalgesia in WT mice but not the Hsp70 KO mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diabetic Swiss Webster mice [1]
Dosage: 2, 10, or 20 mg/kg
Administration: Administered after 8 weeks of diabetes via once per week intra-peritoneal injections.
Result: Improved diabetes induced hypoalgesia and sensory neuron bioenergetic deficits in a dose-dependent manner.
Molecular Weight

447.50

Formula

C24H30FNO6

CAS No.
SMILES

CC(NCCC1=C(C2=CC(F)=CC=C2)C=C(C=C1)O[[email protected]]3[[email protected]@H]([[email protected]@H]([[email protected]](C(C)(O3)C)OC)O)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vivo:
  • 1.

    Cemdomespib (KU-596) is prepared in 0.1 M Captisol (β-cyclodextrin sulfobutylethers) [1].

Purity & Documentation
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Cemdomespib
Cat. No.:
HY-145559
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