1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Epigenetics
    Anti-infection
  2. HSP
    HDAC
    Fungal
  3. HDAC/HSP90-IN-3

HDAC/HSP90-IN-3 

Cat. No.: HY-144694
Handling Instructions

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.

For research use only. We do not sell to patients.

HDAC/HSP90-IN-3 Chemical Structure

HDAC/HSP90-IN-3 Chemical Structure

CAS No. : 2700035-54-5

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Description

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1[1].

IC50 & Target

HSP90

0.83 μM (IC50, fungal Hsp90)

HDAC

0.91 μM (IC50, fungal HDACs)

human HDAC

3.0 μM (IC50, human HDACs)

HSP90

19.52 μM (IC50, human Hsp90)

In Vitro

HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

511.57

Formula

C26H33N5O6

CAS No.
SMILES

CC(C1=CC(C2=NNC(N2C3=CC=C(C=C3)C(NCCCCCCCC(NO)=O)=O)=O)=C(C=C1O)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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HDAC/HSP90-IN-3
Cat. No.:
HY-144694
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