HDAC/HSP90-IN-3
HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.
For research use only. We do not sell to patients.
- CAS No.: 2700035-54-5
- Formula: C26H33N5O6
- Molecular Weight:511.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90 0.83 μM (IC50, fungal Hsp90) |
HDAC 0.91 μM (IC50, fungal HDACs) |
human HDAC 3.0 μM (IC50, human HDACs) |
HSP90 19.52 μM (IC50, human Hsp90) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
4.6 μM
Compound: J5
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Cytotoxicity against human A549 cells assessed as inhibition of cell growth
Cytotoxicity against human A549 cells assessed as inhibition of cell growth
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[PMID: 34742014] |
| HaCaT | IC50 |
>6.13 μM
Compound: J5
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Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth
Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth
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[PMID: 34742014] |
| HEL | IC50 |
4.6 μM
Compound: J5
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Cytotoxicity against human HEL cells assessed as inhibition of cell growth
Cytotoxicity against human HEL cells assessed as inhibition of cell growth
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[PMID: 34742014] |
HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2700035-54-5
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Molecular Weight 511.57
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Formula C26H33N5O6
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SMILES
CC(C1=CC(C2=NNC(N2C3=CC=C(C=C3)C(NCCCCCCCC(NO)=O)=O)=O)=C(C=C1O)O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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