2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Epigenetics Anti-infection
  3. HSP HDAC Fungal
  4. HDAC/HSP90-IN-3

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1.

For research use only. We do not sell to patients.

HDAC/HSP90-IN-3

HDAC/HSP90-IN-3 Chemical Structure

CAS No. : 2700035-54-5

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HDAC/HSP90-IN-3 Related Antibodies

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  • Biological Activity

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Description

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1[1].

IC50 & Target

HSP90

0.83 μM (IC50, fungal Hsp90)

HDAC

0.91 μM (IC50, fungal HDACs)

human HDAC

3.0 μM (IC50, human HDACs)

HSP90

19.52 μM (IC50, human Hsp90)

Cellular Effect
Cell Line Type Value Description References
A549 IC50
4.6 μM
Compound: J5
Cytotoxicity against human A549 cells assessed as inhibition of cell growth
Cytotoxicity against human A549 cells assessed as inhibition of cell growth
[PMID: 34742014]
HaCaT IC50
>6.13 μM
Compound: J5
Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth
Cytotoxicity against human HaCaT cells assessed as inhibition of cell growth
[PMID: 34742014]
HEL IC50
4.6 μM
Compound: J5
Cytotoxicity against human HEL cells assessed as inhibition of cell growth
Cytotoxicity against human HEL cells assessed as inhibition of cell growth
[PMID: 34742014]
In Vitro

HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC/HSP90-IN-3 Related Antibodies
Molecular Weight

511.57

Formula

C26H33N5O6
CAS No.
SMILES

CC(C1=CC(C2=NNC(N2C3=CC=C(C=C3)C(NCCCCCCCC(NO)=O)=O)=O)=C(C=C1O)O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC/HSP90-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC/HSP90-IN-32700035-54-5HSPHDACFungalHeat shock proteinsHistone deacetylaseslow toxicityantifungaldrug resistanceCandida albicanscandidiasisheat shock protein 90 (Hsp90)histone deacetylase (HDAC)invasive fungal infections (IFIs)Inhibitorinhibitorinhibit

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HDAC/HSP90-IN-3
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HY-144694
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