HSP90-IN-19
HSP90-IN-19 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2927442-48-4
- Formule: C29H38O7
- Masse moléculaire:498.61
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 0.27 μM (Hsp90); ＞40 μM (MCF-7); ＞40 (SW480); ＞40 μM (A549); 16.95 μM (HL60); ＞40 μM (SMMC-7721)[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>40 μM
Compound: 31
|
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36274275] |
| HL-60 | IC50 |
16.95 μM
Compound: 31
|
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36274275] |
| MCF7 | IC50 |
>40 μM
Compound: 31
|
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36274275] |
| SMMC-7721 | IC50 |
>40 μM
Compound: 31
|
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36274275] |
| SW480 | IC50 |
>40 μM
Compound: 31
|
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SW480 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36274275] |
In Vitro
HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM[1].
HSP90-IN-19 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) has antiproliferative activity against MCF-7, SW480, A549, HL60 and SMMC-7721 with IC50 values of ＞40 μM, ＞40 μM, ＞40 μM, 16.95 μM and ＞40 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2927442-48-4
-
Masse moléculaire 498.61
-
Formule C29H38O7
-
SMILES
C/C(C)=C\CC[C@]1(CC=C(C2=C([C@@H]1/C=C/OC(/C=C(C)/C)=O)C=C(O2)C)COC(CCC(O)=O)=O)C
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HSP90-IN-19 Related Classifications
HY-152028 Related Classifications
Powered by Bioz