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Cat. No.: HY-143400

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HSP70-IN-3

HSP70-IN-3 is a potent HSP70 inhibitor (IC₅₀s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1.

For research use only. We do not sell to patients.

CAS No.: 2882053-89-4
Formula: C₄₈H₇₈N₆O₇S
Molecular Weight:883.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HSP70-IN-3 Chemical Structure

CAS No.: 2882053-89-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 1.1 μM (HSP70) in ASZ001, 1.9 μM (HSP70) in C3H10T1/2^[1]

All HSP Isoforms :

In Vitro

HSP70-IN-3 (compound 8) (5 μM; 72 hours) has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity in ASZ001 cells^[1].
HSP70-IN-3 can almost completely abolish the expression of Gli1 mRNA in ASZ001 cells after 20-hour incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

ASZ001 cells^[1]
Concentration:

5 μM
Incubation Time:

72 hours
Result:

Showed anti-Hh(Hedgehog signaling) activity and anti-proliferative activity.

Cell Proliferation Assay

Cell Line:

ASZ001 cells^[1]
Concentration:

10 μM
Incubation Time:

48 hours
Result:

After a 20-h incubation with HSP70-IN-3, expression of Gli1 mRNA was almost completely abolished.

Chemical Information

CAS No. 2882053-89-4
Molecular Weight 883.23
Formula C₄₈H₇₈N₆O₇S
SMILES

[H][C@@]12CS[C@@H]([C@@]1(NC(N2)=O)[H])CCCCC(NCCOCCOCCOCCN3C=C(N=N3)CO[C@@H]([C@H]([C@H]4CC[C@]5(/C(CCC[C@]45C)=C/C=C6C[C@H](CCC/6=C)O)[H])C)CCC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wen J, et al. Affinity-based protein profiling identifies vitamin D3 as a heat shock protein 70 antagonist that regulates hedgehog transduction in murine basal cell carcinoma. Eur J Med Chem. 2022;228:114005. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HSP70-IN-3

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HSP70-IN-3 Related Classifications

HY-143400 Related Classifications