1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. HSP70-IN-3

HSP70-IN-3 

Cat. No.: HY-143400
Handling Instructions

HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1.

For research use only. We do not sell to patients.

HSP70-IN-3 Chemical Structure

HSP70-IN-3 Chemical Structure

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Description

HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1[1].

IC50 & Target

IC50: 1.1 μM (HSP70) in ASZ001, 1.9 μM (HSP70) in C3H10T1/2[1]

In Vitro

HSP70-IN-3 (compound 8) (5 μM; 72 hours) has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity in ASZ001 cells[1].
HSP70-IN-3 can almost completely abolish the expression of Gli1 mRNA in ASZ001 cells after 20-hour incubation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 5 μM
Incubation Time: 72 hours
Result: Showed anti-Hh(Hedgehog signaling) activity and anti-proliferative activity.

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: After a 20-h incubation with HSP70-IN-3, expression of Gli1 mRNA was almost completely abolished.
Molecular Weight

883.23

Formula

C48H78N6O7S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
HSP70-IN-3
Cat. No.:
HY-143400
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