2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Stem Cell/Wnt
  3. HSP Hedgehog
  4. HSP70-IN-3

HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1.

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HSP70-IN-3 Chemical Structure

HSP70-IN-3 Chemical Structure

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HSP70-IN-3 Related Antibodies

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Description

HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1[1].

IC50 & Target

IC50: 1.1 μM (HSP70) in ASZ001, 1.9 μM (HSP70) in C3H10T1/2[1]
In Vitro

HSP70-IN-3 (compound 8) (5 μM; 72 hours) has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity in ASZ001 cells[1].
HSP70-IN-3 can almost completely abolish the expression of Gli1 mRNA in ASZ001 cells after 20-hour incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HSP70-IN-3 Related Antibodies

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 5 μM
Incubation Time: 72 hours
Result: Showed anti-Hh(Hedgehog signaling) activity and anti-proliferative activity.

Cell Proliferation Assay

Cell Line: ASZ001 cells[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: After a 20-h incubation with HSP70-IN-3, expression of Gli1 mRNA was almost completely abolished.
Molecular Weight

883.23

Formula

C48H78N6O7S
SMILES

[H][C@@]12CS[C@@H]([C@@]1(NC(N2)=O)[H])CCCCC(NCCOCCOCCOCCN3C=C(N=N3)CO[C@@H]([C@H]([C@H]4CC[C@]5(/C(CCC[C@]45C)=C/C=C6C[C@H](CCC/6=C)O)[H])C)CCC(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HSP70-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSP70-IN-3HSPHedgehogHeat shock proteinsVitamin D3Affinity-based proteinHeat shock protein 70Hedgehog pathwayBasal cell carcinomaInhibitorinhibitorinhibit

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