2882053-89-4
Chemical Structure
HSP70-IN-3
- CAS No.: 2882053-89-4
- Formula:C48H78N6O7S
- Molecular Weight:883.23
IUPAC Name: N-(3-(1H-imidazol-1-yl)propyl)-4-(1-(thiophen-2-ylsulfonyl)-1H-indol-3-yl)butanamide
InChIKey: KVMCXUMPAQRDGQ-FSBLFSHOSA-N
SMILES: [H][C@@]12CS[C@@H]([C@@]1(NC(N2)=O)[H])CCCCC(NCCOCCOCCOCCN3C=C(N=N3)CO[C@@H]([C@H]([C@H]4CC[C@]5(/C(CCC[C@]45C)=C/C=C6C[C@H](CCC/6=C)O)[H])C)CCC(C)C)=O
Biological Activity: HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1[1].
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HSP70-IN-3 | HSP70-IN-3 is a potent HSP70 inhibitor (IC50s of 1.1 and 1.9 μM in ASZ001 and C3H10T1/2, respectively). HSP70-IN-3 has anti-Hh (Hedgehog signaling) activity and anti-proliferative activity and reduces expression of the oncogenic transcription factor GLI1. | |||||||||||||||||||||
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Keywords
