Hsp110 Antibody (YA2613)

Cat. No.: HY-P82868: Data Sheet COA
SDS
User Guide for Antibodies
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Technical Support

Hsp110 Antibody (YA2613) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp110.

For research use only. We do not sell to patients.

Size	Stock	Quantity
Free Sample	Apply now
10 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Hsp110 Antibody (YA2613) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
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Background
Documentation

Description

Hsp110 Antibody (YA2613) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp110.

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 97 kDa;

Observed band size: 105 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q92598

Gene ID

10808 [NCBI]

Immunogen

A synthesized peptide derived from human Hsp105 aa51-99/858.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
IP IP: Immunoprecipitation	1:50

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

Western blot analysis of extracts from HepG2 (lane 2(20μg)), MCF7 (lane 3(20μg)), Hela (lane 3(20μg)), 3T3 (lane 3(20μg)) and PC-12 (lane 5(20μg)) using HSP110 Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (beta Actin, HY-P83730, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

Function：Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity)

Subcellular Localization：Cytoplasm

Expression：
Tissue_specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells

Isoforms & Post-Translational Modification：Q92598 has 4 isomers: Q92598-1: 96865 Da (predicted); Q92598-2: 92116 Da (predicted); Q92598-3: 92255 Da (predicted); Q92598-4: 97460 Da (predicted).
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity

Subunit：Interacts with HSPA8/HSC70 (By similarity). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877)

RRID

AB_3104961

Database

Entrez Gene: 10808 Human ; 15505 Mouse ; 288444 Rat

SwissProt: Q92598 Human ; Q61699 Mouse ; Q66HA8 Rat

OMIM: 610703 Human

Research Field

Signal Transduction

Synonyms

Antigen NY-CO-25; Heat shock protein 105 kDa; HS105; HSP105; HSP105A; HSP105B; HSP110; HSPH1

Documentation

Select Batch:

Data Sheet (234 KB) SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Hsp110 Antibody (YA2613) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Hsp110 Antibody (YA2613)

Hsp110 Antibody (YA2613) Featured Recommendations:

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Hsp110 Antibody (YA2613) Related Classifications

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