HSPH1 - heat shock protein family H (Hsp110) member 1 Gene

Also Known as HSP105; HSP105A; HSP105B; NY-CO-25

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10808

About HSPH1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:31,134,973-31,162,388 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues and 13 paralogues. Broad expression in brain (RPKM 32.5), testis (RPKM 30.3) and 25 other tissues.

Summary

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

HSPH1 Products (12)

mRNA	Protein	Name
XM_017020364.3	XP_016875853.1	heat shock protein 105 kDa isoform X7
XM_017020363.3	XP_016875852.1	heat shock protein 105 kDa isoform X4
NM_001286503.2	NP_001273432.1	heat shock protein 105 kDa isoform 2
XM_011534888.3	XP_011533190.1	heat shock protein 105 kDa isoform X5
XM_011534887.4	XP_011533189.1	heat shock protein 105 kDa isoform X1
NM_001286505.1	NP_001273434.1	heat shock protein 105 kDa isoform 4
XM_005266236.3	XP_005266293.1	heat shock protein 105 kDa isoform X2
XM_047430058.1	XP_047286014.1	heat shock protein 105 kDa isoform X6
NM_006644.4	NP_006635.2	heat shock protein 105 kDa isoform 1
XM_017020362.3	XP_016875851.1	heat shock protein 105 kDa isoform X3
NM_001349704.2	NP_001336633.1	heat shock protein 105 kDa isoform 5
NM_001286504.1	NP_001273433.1	heat shock protein 105 kDa isoform 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables adenyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	24318877	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17024176	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9931472	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21231916	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPH1 Protein Structure

HSP70

0
200
400
600
800
858 a.a.

Protein Preferred Names	Protein Names
heat shock protein 105 kDa	antigen NY-CO-25 heat shock 105kDa/110kDa protein 1

HSPH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSPH1	Q92598	q96be0_human	Homo sapiens	Q96BE0	Lumier	25036637

Cross: Cross-species interaction Intra: Intraspecies interaction

HSPH1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82868	Hsp110 Antibody (YA2613)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Craniotubular Dysplasia, Ikegawa Type	CTDI Craniotubular Dysplasia Ikegawa Type Doid:0112340
Photokeratitis
Craniodiaphyseal Dysplasia	Schaefer Stein Oshman Syndrome CDD Craniodiaphyseal Dysplasia, Dominant Dominantly Inherited Craniodiaphyseal Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06450	HSPH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06451	Hsph1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06452	Hsph1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HSPH1	VGNC	VGNC:106265
Felis catus	HSPH1	VGNC	VGNC:102230
Mus musculus	HSPH1	MGD	MGI:105053
Bos taurus	HSPH1	VGNC	VGNC:53817
Canis familiaris	HSPH1	VGNC	VGNC:59083
Rattus norvegicus	HSPH1	RGD	RGD:1311609
Others	HSPH1	NCBI