1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Apoptosis
  2. HSP
    Apoptosis
  3. YZ129

YZ129 

Cat. No.: HY-114413
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YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration.

For research use only. We do not sell to patients.

YZ129 Chemical Structure

YZ129 Chemical Structure

CAS No. : 1643120-60-8

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Description

YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].

IC50 & Target[1]

HSP90

 

Molecular Weight

300.31

Formula

C₁₉H₁₂N₂O₂

CAS No.

1643120-60-8

SMILES

O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O

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YZ129
Cat. No.:
HY-114413
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