1643120-60-8
1643120-60-8
Chemical Structure
YZ129
- CAS No.: 1643120-60-8
- Formula:C19H12N2O2
- Molecular Weight:300.31
IUPAC Name: 4-(isoquinolin-6-ylamino)naphthalene-1,2-dione
InChIKey: NYDMVPHEEBVAHT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1C(NC2=CC=C(C=NC=C3)C3=C2)=C4)C4=O
Biological Activity: YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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YZ129 | 99.85% | YZ129 is an inhibitor of the HSP90-calcineurin-NFAT pathway against glioblastoma, directly binding to heat shock protein 90 (HSP90) with an IC50 of 820 nM on NFAT nuclear translocation. YZ129-induced GBM cell-cycle arrest at the G2/M phase promotes apoptosis and inhibited tumor cell proliferation and migration. | ||||||||||||||||||||
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References
Keywords
