country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-124109

Copy Link Print Information

TRC051384 hydrochloride

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

TRC051384 hydrochloride is a potent inducer of heat shock protein 70 (HSP70). TRC051384 hydrochloride exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 hydrochloride can be used for the research of ischemic stroke.

For research use only. We do not sell to patients.

CAS No.: 1333327-56-2
Formula: C₂₅H₃₂ClN₅O₄
Molecular Weight:502.01

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TRC051384 hydrochloride Chemical Structure

CAS No.: 1333327-56-2

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All HSP Isoforms :

Chemical Information

CAS No. 1333327-56-2
Molecular Weight 502.01
Formula C₂₅H₃₂ClN₅O₄
SMILES

O=C(NCCN1CCOCC1)NC2=CC=C(C=C2)C(/C=C/C3=NC(N4CCOCC4)=CC=C3)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (6)

All Apoptosis AnalysisRT-PCRWB

Sort by:

Journal Impact Factor

Phytomedicine

Liang-Ge-San inhibits dengue virus serotype 2 infection by reducing caveolin1-induced cytoplasmic heat shock protein 70 translocation into the plasma membrane. [Abstract]

2023 Oct:119:154977. PMID: 37506573
Clin Transl Med

Targeting lysosomal HSP70 induces acid sphingomyelinase-mediated disturbance of lipid metabolism and leads to cell death in T cell malignancies. [Abstract]

2023 Mar;13(3):e1229. PMID: 36959764

TRC051384 hydrochloride purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2023 Mar;13(3):e1229. [Abstract]

Apoptosis rates (%) were determined in Jurkat cells treated with 6 μM V8 and 15 μM ML346 or 10 μM TRC051384 (pretreated for 1 h) compared with control via flow cytometry labelling with Annexin V/PI.
Food Biosci

2025 Nov 17;74:107954.
Commun Biol

Selenoprotein W modulates tau homeostasis in an Alzheimer's disease mouse model. [Abstract]

2024 Jul 17;7(1):872. PMID: 39020075

TRC051384 hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Jul 17;7(1):872. [Abstract]

The heat shock protein inducer TRC051384 (10 μM). ACTB was used as an endogenous reference gene.

TRC051384 hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Jul 17;7(1):872. [Abstract]

HEK293TAU cells were treated with TRC051384 (10 μM), and the samples were collected for western blotting.
J Biotechnol

Interferon inhibitors increase rAAV production in HEK293 cells. [Abstract]

2025 Mar:399:9-18. PMID: 39824361
Domest Anim Endocrin

HSP70 inhibits pig pituitary gonadotrophin synthesis and secretion by regulating the corticotropin-releasing hormone signaling pathway and targeting SMAD3. [Abstract]

2021 Jan;74:106533. PMID: 32992141

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mohanan A, et, al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9. [Content Brief]

[2]. Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50(9):7237-7244. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

TRC051384 hydrochloride

6 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
Chemical Information
Publications (6)
Purity & Documentation
References

1/16
1/16

TRC051384 hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Jul 17;7(1):872. [Abstract]

Customer Validation
The heat shock protein inducer TRC051384 (10 μM). ACTB was used as an endogenous reference gene.
1/16

TRC051384 hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2024 Jul 17;7(1):872. [Abstract]

Customer Validation
HEK293TAU cells were treated with TRC051384 (10 μM), and the samples were collected for western blotting.
1/16

TRC051384 hydrochloride purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2023 Mar;13(3):e1229. [Abstract]

Customer Validation
Apoptosis rates (%) were determined in Jurkat cells treated with 6 μM V8 and 15 μM ML346 or 10 μM TRC051384 (pretreated for 1 h) compared with control via flow cytometry labelling with Annexin V/PI.

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

TRC051384 hydrochloride

Publications Citing Use of MedChemExpress (MCE) TRC051384 hydrochloride

All HSP Isoforms

Biological Activity

Chemical Information

Publications (6)

Purity & Documentation

References

Calculators

Help & FAQs

TRC051384 hydrochloride Related Classifications

HY-124109 Related Classifications