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    Metabolic Enzyme/Protease
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  3. TRC051384

TRC051384 

Cat. No.: HY-101712 Purity: 97.40%
Handling Instructions

TRC051384 is a heat shock protein 70 (HSP70) inducer.

For research use only. We do not sell to patients.

TRC051384 Chemical Structure

TRC051384 Chemical Structure

CAS No. : 867164-40-7

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10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 220 In-stock
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50 mg USD 880 In-stock
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100 mg USD 1400 In-stock
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200 mg USD 2400 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TRC051384 is a heat shock protein 70 (HSP70) inducer.

IC50 & Target[1]

HSP70

 

In Vitro

TRC051384, dose dependently induces HSP70B mRNA by several hundred folds in both HeLa and rat primary mixed neurons. Treatment with TRC051384 results in significant dose-dependent increase in HSF1 transcriptional activity and recovery of luciferase activity. TRC051384 results in 60% inhibition at 6.25 μM and 90% inhibition at 12.5 μM of LPS-induced TNF-α expression in differentiated THP-1 cell line[1].

In Vivo

Treatment with TRC051384 significantly reduces stroke associated neuronal injury (87% reduction in area of penumbra recruited to infarct, and 25% reduction in brain edema) and disability in a rat model of transient ischemic stroke even when administered 8 hours post onset of ischemia. Significant improvement in survival (50% by day2 and 67.3% by day 7) is observed with TRC051384 treatment initiated at 4 hours after ischemia onset. Induction of HSP70 by TRC051384 involves HSF1 activation and results in elevated chaperone and anti-inflammatory activity[1].

Molecular Weight

465.54

Formula

C₂₅H₃₁N₅O₄

CAS No.

867164-40-7

SMILES

O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (214.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1480 mL 10.7402 mL 21.4804 mL
5 mM 0.4296 mL 2.1480 mL 4.2961 mL
10 mM 0.2148 mL 1.0740 mL 2.1480 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

HeLa cell transiently co-transfected with heat shock elements-luciferase reporter and normalization vector, β-galactosidase are treated with vehicle or TRC051384 (12.5 and 25 μM) for 4 hours. Cell lysates are then prepared and analyzed for luciferase and β-galactosidase activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Rats: Injured hemispheres from vehicle treated animals and TRC051384 treated animals are collected at 10-hour post-initiation of tMCAo. Total RNA from each brain sample is extracted followed by cDNA preparation. Each sample of cDNA is analyzed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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KeyWords:

TRC051384 | TRC 051384 | TRC-051384 | HSP | Heat shock proteins | Inhibitor | inhibitor | inhibit

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Product name:
TRC051384
Cat. No.:
HY-101712
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