867164-40-7
867164-40-7
Chemical Structure
TRC051384
- CAS No.: 867164-40-7
- Formula:C25H31N5O4
- Molecular Weight:465.54
IUPAC Name: (E)-1-(2-morpholinoethyl)-3-(4-(3-(6-morpholinopyridin-2-yl)acryloyl)phenyl)urea
InChIKey: SQTSPANZQDCPLB-CMDGGOBGSA-N
SMILES: O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4
Biological Activity: TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke[1][2].
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TRC051384 | 99.79% | TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke. | ||||||||||||||||||||
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TRC051384 (Standard) | ≥98% | TRC051384 (Standard) is the analytical standard of TRC051384 (HY-101712). This product is intended for research and analytical applications. TRC051384 is a potent inducer of heat shock protein 70 (HSP70). TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke. | ||||||||||||||||||||
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References
- [1]. Mohanan A, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60(6):991-9.
- [2]. Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50(9):7237-7244. [Content Brief]
Keywords
