PI3K/mTOR ligand-1

Name: PI3K/mTOR ligand-1
Brand: MedChemExpress
SKU: HY-203618
Rating: 4.5 (0 reviews)

Cat. No.: HY-203618 Purity: 97.28%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC (PI3K/mTOR). PI3K/mTOR ligand-1 can be used to synthesize GP262 (HY-180261).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

PI3K/mTOR ligand-1 화학구조

CAS No. : 1197160-66-9

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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•Related Small Molecules:

•Related Proteins:

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mTOR mTORC1 mTORC2

View All PI3K Isoform Specific Products:

View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
순도&문서
References
고객리뷰

제품 설명

PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC (PI3K/mTOR). PI3K/mTOR ligand-1 can be used to synthesize GP262 (HY-180261)^[1].

IC₅₀ & Target^[1]

p110α

PI3Kα

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-361	IC₅₀	816 nM Compound: 22	Cytotoxicity against human MDA-MB-361 cells Cytotoxicity against human MDA-MB-361 cells	[PMID: 20166697]

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

505.53

화학식

C₂₅H₂₇N₇O₅

CAS No.

1197160-66-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(NC(NC2=CC=C(C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=C2)=O)C=C1)O

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 25 mg/mL (49.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9781 mL	9.8906 mL	19.7812 mL
5 mM	0.3956 mL	1.9781 mL	3.9562 mL
10 mM	0.1978 mL	0.9891 mL	1.9781 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 97.28%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Zhu W, et al. Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway. J Med Chem. 2025 Dec 25;68(24):26188-26205. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9781 mL	9.8906 mL	19.7812 mL	49.4530 mL
	5 mM	0.3956 mL	1.9781 mL	3.9562 mL	9.8906 mL
	10 mM	0.1978 mL	0.9891 mL	1.9781 mL	4.9453 mL
	15 mM	0.1319 mL	0.6594 mL	1.3187 mL	3.2969 mL
	20 mM	0.0989 mL	0.4945 mL	0.9891 mL	2.4727 mL
	25 mM	0.0791 mL	0.3956 mL	0.7912 mL	1.9781 mL
	30 mM	0.0659 mL	0.3297 mL	0.6594 mL	1.6484 mL
	40 mM	0.0495 mL	0.2473 mL	0.4945 mL	1.2363 mL