PI3K/mTOR ligand-1

Name: PI3K/mTOR ligand-1
Brand: MedChemExpress
SKU: HY-203618
Rating: 4.5 (1 reviews)

Cat. No.: HY-203618 Purity: 97.28%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC (PI3K/mTOR). PI3K/mTOR ligand-1 can be used to synthesize GP262 (HY-180261).

For research use only. We do not sell to patients.

PI3K/mTOR ligand-1 Chemical Structure

CAS No. : 1197160-66-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

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View All Isoforms

mTOR mTORC1 mTORC2

View All PI3K Isoform Specific Products:

View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

PI3K/mTOR ligand-1 is a ligand for the target protein of PROTAC (PI3K/mTOR). PI3K/mTOR ligand-1 can be used to synthesize GP262 (HY-180261)^[1].

IC₅₀ & Target^[1]

p110α

PI3Kα

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

505.53

Formula

C₂₅H₂₇N₇O₅

CAS No.

1197160-66-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(NC(NC2=CC=C(C3=NC(N4CCOCC4)=NC(N5CCOCC5)=N3)C=C2)=O)C=C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (49.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9781 mL	9.8906 mL	19.7812 mL
5 mM	0.3956 mL	1.9781 mL	3.9562 mL
10 mM	0.1978 mL	0.9891 mL	1.9781 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.28%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Zhu W, et al. Discovery of the First Potent PI3K/mTOR Dual-Targeting PROTAC Degrader for Efficient Modulation of the PI3K/AKT/mTOR Pathway. J Med Chem. 2025 Dec 25;68(24):26188-26205. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9781 mL	9.8906 mL	19.7812 mL	49.4530 mL
	5 mM	0.3956 mL	1.9781 mL	3.9562 mL	9.8906 mL
	10 mM	0.1978 mL	0.9891 mL	1.9781 mL	4.9453 mL
	15 mM	0.1319 mL	0.6594 mL	1.3187 mL	3.2969 mL
	20 mM	0.0989 mL	0.4945 mL	0.9891 mL	2.4727 mL
	25 mM	0.0791 mL	0.3956 mL	0.7912 mL	1.9781 mL
	30 mM	0.0659 mL	0.3297 mL	0.6594 mL	1.6484 mL
	40 mM	0.0495 mL	0.2473 mL	0.4945 mL	1.2363 mL