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  3. Novobiocin Sodium

Novobiocin Sodium (Synonyms: Albamycin; Cathomycin)

Cat. No.: HY-B0425A
Handling Instructions

Novobiocin Sodium is an antibiotic compound derived from Streptomyces niveus.

For research use only. We do not sell to patients.

Novobiocin Sodium Chemical Structure

Novobiocin Sodium Chemical Structure

CAS No. : 1476-53-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 240 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Novobiocin Sodium purchased from MCE. Usage Cited in: Blood. 2018 Jul 19;132(3):307-320.

    K562, KCL22 and HL60 are treated with the indicated (cytotoxic) concentration of Amidopyrine (AX), Novobiocin (NB) and AUY922 for 48h and later protein lysates are subjected to immunoblot analysis.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Novobiocin Sodium is an antibiotic compound derived from Streptomyces niveus. Target: Antibacterial Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides a member of the order Actinobacteria . Other aminocoumarin antibiotics include clorobiocin and coumermycin A1. The molecular basis of action of novobiocin, and other related drugs clorobiocin and coumermycin A1 has been examined. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved in energy transduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB. The potency of novobiocin is considerably higher than that of the fluoroquinolones that also target DNA gyrase, but at a different site on the enzyme. The GyrA subunit is involved in the DNA nicking and ligation activity [1-4].

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (47.27 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5758 mL 7.8789 mL 15.7577 mL
    5 mM 0.3152 mL 1.5758 mL 3.1515 mL
    10 mM 0.1576 mL 0.7879 mL 1.5758 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    634.61

    Formula

    C₃₁H₃₅N₂NaO₁₁

    CAS No.

    1476-53-5

    SMILES

    CC1=C(OC2=O)C(C(O)=C2NC(C3=CC(C/C=C(C)/C)=C([O-])C=C3)=O)=CC=C1O[[email protected]](OC(C)(C)[[email protected]](OC)[[email protected]]4OC(N)=O)[[email protected]@H]4O.[Na+]

    Shipping

    Room temperature in continental US; may vary elsewhere

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
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    Product Name:
    Novobiocin Sodium
    Cat. No.:
    HY-B0425A
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    Novobiocin Sodium

    Cat. No.: HY-B0425A