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    Antibiotic
  3. Novobiocin Sodium

Novobiocin Sodium (Synonyms: Albamycin; Cathomycin)

Cat. No.: HY-B0425A Purity: 99.12%
Handling Instructions

Novobiocin Sodium (Albamycin; Cathomycin) is an orally active antibiotic compound derived from Streptomyces niveus and a potent DNA gyrase inhibitor by binding the ATP-binding site in the ATPase subunit. Novobiocin Sodium manifests strong anti-bacterial activities effectively against gram-positive pathogens and shows limited activity against gram-negative organisms due to LPS-containing outer membrane.Novobiocin Sodium binds to the C-terminus of Hsp90 and slightly induces degradation of Hsp90-dependent client proteins (IC50=700 µM).

For research use only. We do not sell to patients.

Novobiocin Sodium Chemical Structure

Novobiocin Sodium Chemical Structure

CAS No. : 1476-53-5

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Novobiocin Sodium purchased from MCE. Usage Cited in: Blood. 2018 Jul 19;132(3):307-320.

    K562, KCL22 and HL60 are treated with the indicated (cytotoxic) concentration of Amidopyrine (AX), Novobiocin (NB) and AUY922 for 48h and later protein lysates are subjected to immunoblot analysis.
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    Description

    Novobiocin Sodium (Albamycin; Cathomycin) is an orally active antibiotic compound derived from Streptomyces niveus and a potent DNA gyrase inhibitor by binding the ATP-binding site in the ATPase subunit[1]. Novobiocin Sodium manifests strong anti-bacterial activities effectively against gram-positive pathogens and shows limited activity against gram-negative organisms due to LPS-containing outer membrane.Novobiocin Sodium binds to the C-terminus of Hsp90 and slightly induces degradation of Hsp90-dependent client proteins (IC50=700 µM)[1][2].

    IC50 & Target

    IC50: 700 μM (HSP90)[2]

    In Vitro

    Novobiocin Sodium (0.3 mM; 48 hours) induces a caspase-3/7 enzyme–dependent apoptosis assays with an induction of approximately three- to fivefold of apoptotic cells in K562, HL60, Mutz-2[1].
    Novobiocin (0-500 μM; 15-hours) is against wild type, lptB1lptB1(R144H), and efflux pump-deficient ∆tolC strains with IC50 values of 62.5-125 μM; 0.5 μM; 62.5-125 μM; and 2 μM, respectively[2].

    Western Blot Analysis[2]

    Cell Line: K562, HL60, Mutz-2 cells
    Concentration: 0.3 mM
    Incubation Time: 48 hours
    Result: Decreased caspase-3/7 activity in K562, HL60, Mutz-2 cells.
    Molecular Weight

    634.61

    Formula

    C₃₁H₃₅N₂NaO₁₁

    CAS No.

    1476-53-5

    SMILES

    CC1=C(OC2=O)C(C(O)=C2NC(C3=CC(C/C=C(C)/C)=C(O[Na])C=C3)=O)=CC=C1O[[email protected]](OC(C)(C)[[email protected]](OC)[[email protected]]4OC(N)=O)[[email protected]@H]4O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    H2O : 83.33 mg/mL (131.31 mM; Need ultrasonic)

    DMSO : ≥ 30 mg/mL (47.27 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5758 mL 7.8789 mL 15.7577 mL
    5 mM 0.3152 mL 1.5758 mL 3.1515 mL
    10 mM 0.1576 mL 0.7879 mL 1.5758 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: 99.12%

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    Keywords:

    NovobiocinAlbamycinCathomycinBacterialAutophagyAntibioticK562HL60Mutz-2cellsantibioticInhibitorinhibitorinhibit

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    Novobiocin Sodium
    Cat. No.:
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