2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. JG-98

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.

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JG-98 Chemical Structure

JG-98 Chemical Structure

CAS No. : 1456551-16-8

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Based on 6 publication(s) in Google Scholar

JG-98 Related Antibodies

Top Publications Citing Use of Products

    JG-98 purchased from MedChemExpress. Usage Cited in: Sci Rep. 2019 Oct 7;9(1):14394.  [Abstract]

    Western blot analysis of activated caspase-3 and cleaved PARP in cells non-treated and treated with JG-98 or VER (72 h). Representative immunoblots are shown (n = 2), actin is used as a protein loading control.

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    HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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    Description

    JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3].

    IC50 & Target

    Heat shock protein 70[1]
    In Vitro

    JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM[2].
    JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells[1].
    JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    JG-98 Related Antibodies

    Cell Proliferation Assay[2]

    Cell Line: MCF-7, MDA-MB-231, A375, MeWo, HeLa, HT-29, SKOV3, Jurkat, mouse embryonic fibroblasts (MEF), MM1.R, INA6, RPMI-8226, JJN-3, U266, NCI-H929, L363, MM1.S, KMS11, LP-1, AMO-1, OPM1, OPM2 cells
    Concentration: 30 nM-30 μM
    Incubation Time: 72 hours
    Result: Active against all of the lines tested, and the EC50s were variable (between ~0.3 μM and 4 μM). Normal MEFs and OPM1 and OPM2 were relatively less sensitive.

    Western Blot Analysis[1]

    Cell Line: MDA-MB-231 cells
    Concentration: 10 μM
    Incubation Time: 48 hours
    Result: Incudes apoptotic mediators cleavage of caspase 3 and PARP.
    In Vivo

    JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6-week-old NCR mice (xenografts of MCF7 and HeLa cells)[2]
    Dosage: 3 mg/kg
    Administration: Intraperitoneal injection; on days 0, 2, and 4
    Result: Limited tumor growth, but somewhat less effectively.
    Molecular Weight

    534.54

    Formula

    C24H21Cl2N3OS3
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    CN1/C(SC2=CC(Cl)=CC=C12)=C3S/C(N(CC)C\3=O)=C\C4=[N+](C=CS4)CC5=CC=CC=C5.[Cl-]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (9.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8708 mL 9.3538 mL 18.7077 mL
    5 mM 0.3742 mL 1.8708 mL 3.7415 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.8708 mL 9.3538 mL 18.7077 mL 46.7692 mL
    5 mM 0.3742 mL 1.8708 mL 3.7415 mL 9.3538 mL
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    JG-98 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    JG-981456551-16-8JG98JG 98HSPApoptosisHeat shock proteinsInhibitorinhibitorinhibit

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