1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
    Apoptosis
  2. HSP
    Apoptosis
  3. JG-98

JG-98 

Cat. No.: HY-117282 Purity: 99.97%
Handling Instructions

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages.

For research use only. We do not sell to patients.

JG-98 Chemical Structure

JG-98 Chemical Structure

CAS No. : 1456551-16-8

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Description

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3].

IC50 & Target

Heat shock protein 70[1]

In Vitro

JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM[2].
JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells[1].
JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27[2].

Cell Proliferation Assay[2]

Cell Line: MCF-7, MDA-MB-231, A375, MeWo, HeLa, HT-29, SKOV3, Jurkat, mouse embryonic fibroblasts (MEF), MM1.R, INA6, RPMI-8226, JJN-3, U266, NCI-H929, L363, MM1.S, KMS11, LP-1, AMO-1, OPM1, OPM2 cells
Concentration: 30 nM-30 μM
Incubation Time: 72 hours
Result: Active against all of the lines tested, and the EC50s were variable (between ~0.3 μM and 4 μM). Normal MEFs and OPM1 and OPM2 were relatively less sensitive.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 10 μM
Incubation Time: 48 hours
Result: Incudes apoptotic mediators cleavage of caspase 3 and PARP.
In Vivo

JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells[2].

Animal Model: 6-week-old NCR mice (xenografts of MCF7 and HeLa cells)[2]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; on days 0, 2, and 4
Result: Limited tumor growth, but somewhat less effectively.
Molecular Weight

534.54

Formula

C₂₄H₂₁Cl₂N₃OS₃

CAS No.

1456551-16-8

SMILES

CN1/C(SC2=CC(Cl)=CC=C12)=C3S/C(N(CC)C\3=O)=C\C4=[N+](C=CS4)CC5=CC=CC=C5.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.35 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8708 mL 9.3538 mL 18.7077 mL
5 mM 0.3742 mL 1.8708 mL 3.7415 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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JG-98
Cat. No.:
HY-117282
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