1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

Apoptozole 

Cat. No.: HY-15098 Purity: 99.57%
Data Sheet SDS Handling Instructions

Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity.

For research use only. We do not sell to patients.
Apoptozole Chemical Structure

Apoptozole Chemical Structure

CAS No. : 1054543-47-3

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $76 In-stock
5 mg $55 In-stock
10 mg $95 In-stock
50 mg $410 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. target: Hsp70 [1] In vitro: Apoptozole binds HSP70 but not other types of heat shock proteins and induces caspase-dependent apoptosis. Apoptozole does not affect interactions of HSP70 with ASK1, JNK, BAX, and AIF. [1] Apoptozole aggregates under aqueous conditions. [2] In vivo: Animal studies indicate that Az treatment retards tumor growth in a xenograft mouse model without affecting mouse viability. [1]

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.5986 mL 7.9928 mL 15.9857 mL
5 mM 0.3197 mL 1.5986 mL 3.1971 mL
10 mM 0.1599 mL 0.7993 mL 1.5986 mL
References
M.Wt

625.56

Formula

C₃₃H₂₅F₆N₃O₃

CAS No.

1054543-47-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Apoptozole
Cat. No.:
HY-15098
Quantity: