1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

NVP-HSP990 (Synonyms: HSP-990)

Cat. No.: HY-15190 Purity: 98.59%
Data Sheet SDS Handling Instructions

NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90α) with potential antineoplastic activity.

For research use only. We do not sell to patients.
NVP-HSP990 Chemical Structure

NVP-HSP990 Chemical Structure

CAS No. : 934343-74-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 139 In-stock
5 mg USD 126 In-stock
10 mg USD 198 In-stock
50 mg USD 660 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


NVP-HSP990(HSP990) is an orally bioavailable inhibitor of Hsp90(IC50=13 nM; Hsp90α) with potential antineoplastic activity. IC50 value: 13 nM(Hsp90α) [1] Target: Hsp90 inhibitor in vitro: NVP-HSP990 triggered apoptosis in a panel of human multiple myeloma cells, induced cell-cycle arrest, PARP cleavage, downregulation of client proteins, the inability to reactivate phospho-STAT3 following exogenous IL-6 stimulation, and it synergized with azacytidine and bortezomib in cell lines and primary multiple myeloma samples [2]. Exposure of MM cells to a combination of NVP-HSP990 and either melphalan or histone deacetylase (HDAC) inhibitors caused synergistic inhibition of viability, increased induction of apoptosis, and was able to overcome the primary resistance of the cell line RPMI-8226 to HSP90 inhibition [3]. in vivo: HSP990 was given to control mice every 3 days for 14 days at close to the maximum tolerated dose, which was most likely to reveal any effect on phototransduction machinery biogenesis. HSP990-treated retinae showed a significant reduction in GRK1 levels, compared with vehicle-treated control. Moreover, HSP990-treated retinae exhibited retinal morphology that was indistinguishable from age-matched vehicle-treated animals, with rhodopsin localized in the OS [4].

Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 33 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 98.59%

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