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HM03 trihydrochloride

4 Cited Publications

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HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity.

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CAS No.: 1082532-95-3
Formule: C₂₆H₃₀Cl₄N₄O₂
Masse moléculaire:572.35

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Data Sheet (269 KB)

HM03 trihydrochloride Chemical Structure

CAS No.: 1082532-95-3

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Activité biologique
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- In Vitro
Chemical Information
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Description

HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity^[1].

IC₅₀ & Target

HSPA5

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In Vitro

HM03 trihydrochloride (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells^[1].
HM03 trihydrochloride forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins^[1].
HM03 trihydrochloride exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1082532-95-3
Masse moléculaire 572.35
Formule C₂₆H₃₀Cl₄N₄O₂
SMILES

OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5.[H]Cl.[H]Cl.[H]Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Proc Natl Acad Sci U S A

COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis. [Abstract]

2023 May 23;120(21):e2217119120. PMID: 37186819
Bioorg Chem

Identification of FTY720 and COH29 as novel topoisomerase I catalytic inhibitors by experimental and computational studies. [Abstract]

2024 Jun:147:107412. PMID: 38696845
iScience

Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish. [Abstract]

2023 Oct 13;26(11):108207. PMID: 37942006
bioRxiv

Genome-Wide Screens Identify Core Regulators of Cell Surface Prion Protein Expression. [Abstract]

2025 Dec 9:2025.12.07.692843. PMID: 41427295

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044-3050. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HM03 trihydrochloride

4 Cited Publications

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HM03 trihydrochloride

Publications Citing Use of MedChemExpress (MCE) HM03 trihydrochloride

Voir tous les produits spécifiques à Isoform HSP

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Chemical Information

Publications (4)

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HM03 trihydrochloride Related Classifications

Cat. No.: HY-125974A