1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. HM03 trihydrochloride

HM03 trihydrochloride 

Cat. No.: HY-125974A
Handling Instructions

HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity.

For research use only. We do not sell to patients.

HM03 trihydrochloride Chemical Structure

HM03 trihydrochloride Chemical Structure

CAS No. : 1082532-95-3

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Description

HM03 trihydrochloride is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 trihydrochloride has anticancer activity[1].

In Vitro

HM03 trihydrochloride (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1].
HM03 trihydrochloride forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1].
HM03 trihydrochloride exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1].

Molecular Weight

572.35

Formula

C₂₆H₃₀Cl₄N₄O₂

CAS No.

1082532-95-3

SMILES

OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5.[H]Cl.[H]Cl.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

HM03 trihydrochlorideHSPHeat shock proteinsheatshockproteincancercellHCT116tumorInhibitorinhibitorinhibit

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HM03 trihydrochloride
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HY-125974A
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