1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP
  3. HM03

HM03 

Cat. No.: HY-125974 Purity: 98.06%
Handling Instructions

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity.

For research use only. We do not sell to patients.

HM03 Chemical Structure

HM03 Chemical Structure

CAS No. : 500565-15-1

Size Price Stock Quantity
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].

IC50 & Target[1]

HSPA5

 

In Vitro

HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1].
HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1].
HM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1].

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 0.1, 1, 10, 25, 50 μM
Incubation Time: 72 hours
Result: Exhibited prominent inhibition effect (18% survival at 25 µM).
Molecular Weight

462.97

Formula

C₂₆H₂₇ClN₄O₂

CAS No.

500565-15-1

SMILES

OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (270.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1600 mL 10.7998 mL 21.5997 mL
5 mM 0.4320 mL 2.1600 mL 4.3199 mL
10 mM 0.2160 mL 1.0800 mL 2.1600 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (13.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

HM03HM 03HM-03HSPHeat shock proteinsheatshockproteincancercellHCT116tumorInhibitorinhibitorinhibit

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Product Name:
HM03
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HY-125974
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