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  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. HspB8 Antibody (YA2617)

HspB8 Antibody (YA2617) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HspB8.

For research use only. We do not sell to patients.

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50 μL In-stock
100 μL In-stock
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

HspB8 Antibody (YA2617) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HspB8.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 22 kDa;
Observed band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human HSPB8/HSP22 aa5-32.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:1000-1:2000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:100-1:200
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Involved in the chaperone-assisted selective autophagy (CASA), a crucial process for protein quality control, particularly in mechanical strained cells and tissues such as muscle. Displays temperature-dependent chaperone activity
Subcellular Localization：Cytoplasm; Nucleus
Expression：
Tissue_specificity:It is mainly expressed in skeletal muscle and heart.

Induction:By 17-beta-estradiol
Subunit：Monomer. Forms a ternary complex with BAG3 and HSPA1A (PubMed:27884606). Component of the chaperone-assisted selective autophagy (CASA) complex consisting of BAG3, HSPA8/HSC70, HSPB8 and STUB1/CHIP (PubMed:20060297). Interacts with HSPB1 (PubMed:11342557). Interacts with DNAJB6 (PubMed:22366786). Interacts with BAG3 (PubMed:28144995)
Database

Entrez Gene: 26353 Human ; 80888 Mouse ; 113906 Rat

SwissProt: Q9UJY1 Human ; Q9JK92 Mouse ; Q9EPX0 Rat

OMIM: 158590 Human

Research Field

Signal Transduction
Synonyms
HSPB8; CRYAC; E2IG1; HSP22; PP1629; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
Documentation
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

HspB8 Antibody (YA2617) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
HspB8 Antibody (YA2617)
Cat. No.:
HY-P82872
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English - EN (252 KB)

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