GRP78 BiP Antibody (YA746)

Cat. No.: HY-P80696: FAQs
Data Sheet SDS COA User Guide for Antibodies

GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

For research use only. We do not sell to patients.

Size	Price	Stock	Quantity
Free Sample		Apply now
10 μL	$70	In-stock	Estimated Time of Arrival: December 31
50 μL	$185	In-stock	Estimated Time of Arrival: December 31
100 μL	$300	In-stock	Estimated Time of Arrival: December 31
250 μL		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

Biological Activity
Technical Parameters
Properties
Documentation

Description	GRP78 BiP Antibody (YA746) is a non-conjugated and Mouse origined monoclonal antibody about 72 kDa, targeting to GRP78 BiP (4F11). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.
Background	GRP78 BiP (4F11): The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]
Tag	Free
Gene ID	3309
Synonyms	HSPA5; GRP78; 78 kDa glucose-regulated protein; GRP-78; Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP
Molecular Weight	Predicted band size: 72 kDa
Purity	affinity purified
Conjugation	Non-conjugated
Research Field	Tags & Cell Markers
Product Categories	Primary Antibody; Mouse Monoclonal Antibody
Host	Mouse
Reactivity	Human, Mouse, Rat
SwissProt ID	P11021
Dilution Ratio	WB: 1:500-1:1,000 ;IF: 1:50-1:200 ;IP: 1:20
Application	WB, ICC/IF, IP
Appearance	Liquid
Formulation	Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA. Preservative: 0.02% sodium azide.
Storage & Stability	Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping	Shipping with blue ice.
Isotype	IgG2b
Immunogen	Synthetic peptide corresponding to Human BiP/GRP78.The exact sequence is proprietary to MCE.
Documentation	Select Batch: Data Sheet (235 KB) SDS (251 KB) COA (205 KB) User Guide for Antibodies (1077 KB)

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks

Product Name			Lot #
Applicant Name *			Country or Region *
Email Address *
Phone Number *			Organization Name *
Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

GRP78 BiP Antibody (YA746)

Biological Activity

Technical Parameters

Properties

Documentation

Your Recently Viewed Products:

Request for HNMR Report

Request for HNMR Report