HSPA5 - heat shock protein family A (Hsp70) member 5 Gene

Also Known as BIP; GRP78; HEL-S-89n

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3309

About HSPA5

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:125,234,853-125,241,343 (from NCBI)

This gene has 15 transcripts (splice variants), 248 orthologues and 13 paralogues. Broad expression in thyroid (RPKM 442.6), bone marrow (RPKM 284.6) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral Infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular Apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of Cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020]

HSPA5 Products (1)

mRNA	Protein	Name
NM_005347.5	NP_005338.1	endoplasmic reticulum chaperone BiP precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	26655470	GOA
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	20335166	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables misfolded protein binding	IDA IDA: Inferred from direct assay	18400946	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11907036	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12411443	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	8666824	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	10085239	GOA
involved in maintenance of protein localization in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	23990668	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10760948	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	23990668	GOA
involved in post-translational protein targeting to membrane, translocation	IMP IMP: Inferred from mutant phenotype	29719251	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22689054	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22689054	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16223484	GOA
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	11943137	GOA
part of endoplasmic reticulum chaperone complex	IDA IDA: Inferred from direct assay	18400946	GOA
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	21289099	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11181571	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	22689054	GOA
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	22689054	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	11943137	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA5 Protein Structure

HSP70

0
200
400
600
654 a.a.

Protein Preferred Names	Protein Names
endoplasmic reticulum chaperone BiP	78 kDa glucose-regulated protein HSP70 family protein 5 binding-immunoglobulin protein endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 epididymis secretory sperm binding protein Li 89n glucose-regulated protein, 78kDa heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) heat shock protein 70 family protein 5 heat shock protein family A member 5 immunoglobulin heavy chain-binding protein

HSPA5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSPA5	P11021	PDIA6	Homo sapiens	Q15084	TAP	24189400
Intra	HSPA5	P11021	HYOU1	Homo sapiens	Q9Y4L1	Crosslink	30021884
Intra	HSPA5	P11021	HYOU1	Homo sapiens	Q9Y4L1	Anti Tag CoIP	26496610
Intra	HSPA5	P11021	UGGT2	Homo sapiens	Q9NYU1	Anti Tag CoIP	33961781
Cross	HSPA5	P11021	S	Human betacoronavirus	K0BRG7	Anti Bait CoIP	29887526
Cross	HSPA5	P11021	S	SARS-CoV-2	P0DTC2	Anti Tag CoIP	33965375
Cross	HSPA5	P11021	S	SARS-CoV-2	P0DTC2	Confocal	33965375
Cross	HSPA5	P11021	S	SARS-CoV-2	P0DTC2	PLA	33965375
Intra	HSPA5	P11021	SIL1	Homo sapiens	Q9H173	Anti Tag CoIP	24473200
Intra	HSPA5	P11021	SEC61A1	Homo sapiens	P61619	Peptide Array	22796945
Intra	HSPA5	P11021	SEC61A1	Homo sapiens	P61619	SPR	22796945
Intra	HSPA5	P11021	HSP90B1	Homo sapiens	P14625	Anti Tag CoIP	26496610
Intra	HSPA5	P11021	RAF1	Homo sapiens	P04049	Pull Down	18064632
Intra	HSPA5	P11021	RAF1	Homo sapiens	P04049	Anti Bait CoIP	18064632
Intra	HSPA5	P11021	RAF1	Homo sapiens	P04049	Cosedimentation	18064632
Intra	HSPA5	P11021	PAWR	Homo sapiens	Q96IZ0	Anti Tag CoIP	19632185
Intra	HSPA5	P11021	PAWR	Homo sapiens	Q96IZ0	Anti Bait CoIP	19632185
Intra	HSPA5	P11021	PAWR	Homo sapiens	Q96IZ0	Confocal	19632185
Intra	HSPA5	P11021	DNAJB11	Homo sapiens	Q9UBS4	Pull Down	18923428
Intra	HSPA5	P11021	DNAJB11	Homo sapiens	Q9UBS4	TAP	24189400
Intra	HSPA5	P11021	ACE2	Homo sapiens	Q9BYF1	Pull Down	33965375
Intra	HSPA5	P11021	ACE2	Homo sapiens	Q9BYF1	PLA	33965375
Intra	HSPA5	P11021	ACE2	Homo sapiens	Q9BYF1	Confocal	33965375
Intra	HSPA5	P11021	ACE2	Homo sapiens	Q9BYF1	Anti Tag CoIP	33965375
Intra	HSPA5	P11021	DMKN	Homo sapiens	Q6E0U4	Anti Bait CoIP	22735594
Cross	HSPA5	P11021	Cnpy2	Mus musculus	Q9QXT0	Anti Tag CoIP	28869608
Intra	HSPA5	P11021	ATF6	Homo sapiens	P18850	Anti Bait CoIP	27238082
Cross	HSPA5	P11021	Pawr	Rattus norvegicus	Q62627	Pull Down	19632185
Cross	HSPA5	P11021	Pawr	Rattus norvegicus	Q62627	Anti Tag CoIP	19632185

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSPA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72239	HSPA5/GRP-78 Protein, Human (His)	P11021 (E25-E293)	≥ 90%, as determined by reducing SDS-PAGE.

HSPA5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80496	GRP78 BiP Antibody (YA745)	WB, IHC-P, ICC/IF	Human, Mouse
HY-P80696	GRP78 BiP Antibody (YA746)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P80696A	GRP78 BiP Antibody (YA746)(PBS only)	WB, ICC/IF, IP	Human, Mouse, Rat
HY-P84053	GRP78 BiP Antibody (YA3750)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P84053A	GRP78 BiP Antibody (YA3750)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat, Monkey, Rabbit
HY-P85741	GRP78 BiP Antibody (YA5433)	WB, IHC-P, ICC/IF	Human, Rat
HY-P86510	GRP78 BiP Antibody (YA6202)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Borna Disease	Enzootic Encephalomyelitis
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Acute Orbital Inflammation	Acute Inflammation Of Orbit
Cavernous Sinus Thrombosis	Thrombosis Of Cavernous Venous Sinus
Orbital Cellulitis	Cellulitis Of Orbit
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Mucormycosis	Zygomycosis Disseminated Mucormycosis Absidia Infection Absidia Mucoromycosis Cunninghamella Infection Cunninghamella Mucoromycosis Infection By Absidia Spp Infection By Rhizopus Spp Mucor Infection Mucor Mucoromycosis Infection By Mucor Spp Rhizopus Infection Rhizopus Mucoromycosis Infection By Cunninghamella Spp Phycomycosis Nos
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus	Wolcott-Rallison Syndrome Med-Iddm Syndrome Iddm-Med Syndrome Wolcott Rallison Syndrome WRS Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Diabetes Mellitus	Diabetes
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Intracranial Sinus Thrombosis	Sinus Thrombosis, Intracranial
Microcephaly 7, Primary, Autosomal Recessive	MCPH7 Primary Autosomal Recessive Microcephaly 7 Microcephaly, Primary Autosomal Recessive, 7
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Ischemia	Acute Coronary Syndrome
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Conidiobolomycosis	Infection By Conidiobolus Rhinoentomophthoromycosis Entomophthoromycosis Conidiobolae
Halothane Hepatitis	Hepatitis Halothane
Autoimmune Cardiomyopathy
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Marinesco-Sjogren Syndrome	Marinesco-Sjögren Syndrome MSS Marinesco-Garland Syndrome Garland-Moorhouse Syndrome Hereditary Oligophrenic Cerebello-Lental Degeneration Oligophrenic Cerebellolenticular Degeneration Marinesco-Sjogren Syndrome-Hypergonadotrophic Hypogonadism Marinesco-Sjogren Syndrome-Myopathy Marinesco-Sjogren-Garland Syndrome Marinesco-Sjoegren Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W250122	Glutamic acid sodium salt	Activator	99.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125974	HM03	Inhibitor	99.51%	Unkown
HY-152153	GRP78-IN-3	Inhibitor	99.88%	Unkown
HY-125974A	HM03 trihydrochloride	Inhibitor	/	Unkown
HY-184982	Estrogen receptor-IN-2	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSPA5	MGD	MGI:95835
Canis familiaris	HSPA5	VGNC	VGNC:55608
Macaca mulatta	HSPA5	VGNC	VGNC:103272
Rattus norvegicus	HSPA5	RGD	RGD:2843
Bos taurus	HSPA5	VGNC	VGNC:59220
Felis catus	HSPA5	VGNC	VGNC:102938
Others	HSPA5	NCBI