HSP90B1 - heat shock protein 90 beta family member 1 Gene

Also Known as ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7184

About HSP90B1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,930,410-103,947,926 (from NCBI)

This gene has 35 transcripts (splice variants), 224 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 807.9), appendix (RPKM 260.4) and 24 other tissues.

Summary

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding Other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a MicroRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

HSP90B1 Products (1)

mRNA Protein Name
NM_003299.3 NP_003290.1 endoplasmin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
11958450 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9596688 GOA
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
19000834 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
18264092 GOA
acts upstream of or within actin rod assembly IDA
IDA: Inferred from direct assay
19000834 GOA
acts upstream of or within cellular response to ATP IDA
IDA: Inferred from direct assay
19000834 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10497210 GOA
involved in response to hypoxia IDA
IDA: Inferred from direct assay
15620698 GOA
involved in retrograde protein transport, ER to cytosol IMP
IMP: Inferred from mutant phenotype
25660456 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
9596688 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17344063 GOA
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
10497210 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
10497210 GOA
located in midbody IDA
IDA: Inferred from direct assay
15166316 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
10497210 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
23349634 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSP90B1 Protein Structure

HATPase_c_3

HATPase_c_3: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (95 - 229)

HSP90

HSP90: Hsp90 protein (257 - 783)

  • 0
  • 200
  • 400
  • 600
  • 803 a.a.
Protein Preferred Names Protein Names

endoplasmin

  • 94 kDa glucose-regulated protein

HSP90B1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSP90B1 P14625 HSPA5 Homo sapiens P11021
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

HSP90B1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82774 GRP94 Antibody (YA2519) WB, IHC-P, ICC/IF Human, Mouse
HY-P86194 GRP94 Antibody (YA5886) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Pelizaeus-Merzbacher-Like Disease

  • Pmld
Prion Disease

  • Spongiform Encephalopathy

  • Transmissible Spongiform Encephalopathies

  • Prion Diseases

  • Prion Disease Pathway

  • Transmissible Spongiform Encephalopathy

  • Prion Induced Disorder

  • Prion Protein Disease

  • Inherited Human Transmissible Spongiform Encephalopathies

  • Prion Protein Diseases

  • Prion-Associated Disorders

  • Prion-Induced Disorders

  • Transmissible Dementias

  • Tses

  • Human Prion Disease

  • Tse

  • Encephalopathy, Transmissible Spongiform

  • Prion Disease, Susceptibility To

  • Spongiform Encephalopathies

  • Human Transmissible Spongiform Encephalopathies, Inherited
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

  • PLSD-T

  • PLSDT

  • Platyspondylic Dysplasia, Torrance Type

  • Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type

  • Thanatophoric Dysplasia, Torrance Variant

  • Platyspondylic Skeletal Dysplasia, Torrance Type

  • Torrance Type Platyspondylic Dysplasia

  • Platyspondylic Dysplasia, Torrance-Luton Type

  • Platyspondylic Lethal Skeletal Dysplasia Torrance Type

  • Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type

  • Thanatophoric Dysplasia Torrance Variant

  • Platyspondylic Chondrodysplasia, Torrance-Luton Type

  • Plsd-Tl

  • Dysplasia, Skeletal, Platyspondylic, Torrance Type
Pseudoachondroplasia

  • PSACH

  • Pseudoachondroplastic Dysplasia

  • Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome

  • Spondyloepiphyseal Dysplasia, Pseudoachondroplastic

  • Pseudoachondroplastic Spondyloepiphyseal Dysplasia

  • Spondyloepiphyseal Dysplasia Pseudoachondroplastic
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10214 SNX-2112 99.49% Unkown
HY-N2445 Flavokawain C 99.79% Unkown
HY-170820 XYD049 Inhibitor 99.46% Unkown
HY-RS06419 HSP90B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21240 Hsp90b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27757 Hsp90b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HSP90B1 MGD MGI:98817
Felis catus HSP90B1 VGNC VGNC:84033
Bos taurus HSP90B1 VGNC VGNC:49984
Rattus norvegicus HSP90B1 RGD RGD:1310482
Macaca mulatta HSP90B1 VGNC VGNC:97776
Canis familiaris HSP90B1 VGNC VGNC:54212
Others HSP90B1 NCBI