Glutamic acid sodium salt
Based on 1 publication(s) in Google Scholar
Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders.
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- Pureté: 99.92%
- CAS No.: 32221-81-1
- Formule: C5H8NNaO4
- Masse moléculaire:169.11
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Stockage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Glutamic acid sodium salt
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Activité biologique
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Grp78 |
HSPA5 |
Bcl-2 |
Monosodium glutamate (20 mM; 12-24 h) induces apoptotic cell death in C6 astrocytic cells by promoting reactive oxygen species generation, glutathione depletion, mitochondrial dysfunction, and endoplasmic reticulum stress[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C6 astrocytic cells
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Concentration:20 mM
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Incubation Time:12 h
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Result:Up-regulated protein levels of CHOP, Grp78, and Bcl-2.
Monosodium glutamate (4 mg/g b.w.; i.p.) induces liver and kidney damage in Wistar rats[3].
Monosodium glutamate (8 mg/kg; p.o. via drinking water; 1 month) impairs cognitive behavior in male Swiss albino mice, and its combination with Aspartame (HY-B0361) exacerbates neurotransmitter (dopamine, serotonin) reduction and oxidative stress in the forebrain[4].
Monosodium glutamate (100-500 mg/kg; p.o.; daily for 21 days) induces depressive-like behavior, brain oxidative stress, and elevated liver enzymes in male Swiss mice[5].
Monosodium glutamate (300 mg/kg; p.o.; 21 days) reduces pain threshold and increases brain nitric oxide levels in male NMRI mice, inducing hyperalgesia[6].
Monosodium glutamate (4 g/kg b.w.; s.c.; once daily for 7 consecutive days) induces obesity and insulin resistance in female ICR mice[7].
Monosodium glutamate (0.5%-5% in diet or oral gavage) does not affect pulmonary inflammation, Th2 cytokine production, IgE levels, or airway hyperresponsiveness in Ovalbumin-induced asthmatic BALB/c mice[8].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (225-250 g)[3]
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Dosage:4 mg/g b.w.
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Administration:Intraperitoneal injection
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Result:Caused turbid swelling, vacuolar degeneration and necrosis in the liver, glomerular compaction and tubular destruction in the kidneys.
Increased serum ALAT, ASAT and lipid peroxidation products (MDA, 4-HDA).
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 32221-81-1
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Appearance Solid
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Masse moléculaire 169.11
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Formule C5H8NNaO4
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Color White to off-white
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SMILES
O=C(CCC(C(O)=O)N)O[Na]
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Synonyms
Monosodium glutamate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Microorganisms
Monosodium Glutamate Inhibits Pseudomonas aeruginosa-Induced Acute Lung Injury by Targeting the Type III Secretion Systems and Modulating Host Immunity. [Abstract]2026 Mar 23;14(3):725. PMID: 41900484
Solvant et solubilité
H2O : 250 mg/mL (1478.33 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Park E, et al. Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death. Food Chem Toxicol. 2014 May;67:1-9. [Content Brief]
[2]. Rycerz K, et al. Effects of monosodium glutamate treatment on calretinin-immunoreactive neurons in hippocampus of postnatal rats. Folia Histochem Cytobiol. 2014;52(4):281-8. [Content Brief]
[3]. Ortiz GG, et al. Monosodium glutamate-induced damage in liver and kidney: a morphological and biochemical approach. Biomed Pharmacother. 2006 Feb;60(2):86-91. [Content Brief]
[4]. Abu-Taweel GM, et al. Cognitive and biochemical effects of monosodium glutamate and aspartame, administered individually and in combination in male albino mice. Neurotoxicol Teratol. 2014 Mar-Apr;42:60-7. [Content Brief]
[6]. Zanfirescu A, et al. Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice. Nutrients. 2017 Dec 21;10(1):1 [Content Brief]
[7]. Zhang N , et al. Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate. Acta Pharmacol Sin. 2010 Jan;31(1):35-42. [Content Brief]
[8]. Yoneda J, et al. Effects of oral monosodium glutamate in mouse models of asthma. Food Chem Toxicol. 2011 Jan;49(1):299-304. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 5.9133 mL | 29.5666 mL | 59.1331 mL | 147.8328 mL |
| 5 mM | 1.1827 mL | 5.9133 mL | 11.8266 mL | 29.5666 mL | |
| 10 mM | 0.5913 mL | 2.9567 mL | 5.9133 mL | 14.7833 mL | |
| 15 mM | 0.3942 mL | 1.9711 mL | 3.9422 mL | 9.8555 mL | |
| 20 mM | 0.2957 mL | 1.4783 mL | 2.9567 mL | 7.3916 mL | |
| 25 mM | 0.2365 mL | 1.1827 mL | 2.3653 mL | 5.9133 mL | |
| 30 mM | 0.1971 mL | 0.9856 mL | 1.9711 mL | 4.9278 mL | |
| 40 mM | 0.1478 mL | 0.7392 mL | 1.4783 mL | 3.6958 mL | |
| 50 mM | 0.1183 mL | 0.5913 mL | 1.1827 mL | 2.9567 mL | |
| 60 mM | 0.0986 mL | 0.4928 mL | 0.9856 mL | 2.4639 mL | |
| 80 mM | 0.0739 mL | 0.3696 mL | 0.7392 mL | 1.8479 mL | |
| 100 mM | 0.0591 mL | 0.2957 mL | 0.5913 mL | 1.4783 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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