32221-81-1
Chemical Structure
Glutamic acid sodium salt
Synonym(s): Monosodium glutamate
- CAS No.: 32221-81-1
- Formula:C5H8NNaO4
- Molecular Weight:169.11
IUPAC Name: sodium 4-amino-4-carboxybutanoate
InChIKey: LPUQAYUQRXPFSQ-UHFFFAOYSA-M
SMILES: O=C(CCC(C(O)=O)N)O[Na]
Biological Activity: Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders[1][2][3][4][5][6][7][8].
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Glutamic acid sodium salt | 99.92% | Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders. | ||||||||||||||||||||
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- [1]. Park E, et al. Protective effects of N-acetylcysteine against monosodium glutamate-induced astrocytic cell death. Food Chem Toxicol. 2014 May;67:1-9. [Content Brief]
- [2]. Rycerz K, et al. Effects of monosodium glutamate treatment on calretinin-immunoreactive neurons in hippocampus of postnatal rats. Folia Histochem Cytobiol. 2014;52(4):281-8. [Content Brief]
- [3]. Ortiz GG, et al. Monosodium glutamate-induced damage in liver and kidney: a morphological and biochemical approach. Biomed Pharmacother. 2006 Feb;60(2):86-91. [Content Brief]
- [4]. Abu-Taweel GM, et al. Cognitive and biochemical effects of monosodium glutamate and aspartame, administered individually and in combination in male albino mice. Neurotoxicol Teratol. 2014 Mar-Apr;42:60-7. [Content Brief]
- [5]. Umukoro S, et al. Effect of monosodium glutamate on behavioral phenotypes, biomarkers of oxidative stress in brain tissues and liver enzymes in mice[J]. World Journal of neuroscience, 2015, 5(5): 339-349.
- [6]. Zanfirescu A, et al. Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice. Nutrients. 2017 Dec 21;10(1):1 [Content Brief]
- [7]. Zhang N , et al. Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate. Acta Pharmacol Sin. 2010 Jan;31(1):35-42. [Content Brief]
- [8]. Yoneda J, et al. Effects of oral monosodium glutamate in mouse models of asthma. Food Chem Toxicol. 2011 Jan;49(1):299-304. [Content Brief]
Keywords
