country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

SEC61A1 - SEC61 translocon subunit alpha 1 Gene

Also Known as HNFJ4; SEC61; ADTKD5; HSEC61; SEC61A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29927

About SEC61A1

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:128,051,641-128,071,683 (from NCBI)

This gene has 22 transcripts (splice variants), 283 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 81.0), placenta (RPKM 70.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric Sec61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]

SEC61A1 Products (3)

mRNA	Protein	Name
NM_001400328.1	NP_001387257.1	protein transport protein Sec61 subunit alpha isoform 1 isoform 2
NM_001400329.1	NP_001387258.1	protein transport protein Sec61 subunit alpha isoform 1 isoform 3
NM_013336.4	NP_037468.1	protein transport protein Sec61 subunit alpha isoform 1 isoform 1

SEC61A1 Protein Structure

Plug_translocon

SecY

0
100
200
300
400
476 a.a.

Protein Preferred Names	Protein Names
protein transport protein Sec61 subunit alpha isoform 1	SEC61 translocon alpha 1 subunit

SEC61A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SEC61A1	P61619	HSPA5	Homo sapiens	P11021	Peptide Array	22796945
Intra	SEC61A1	P61619	CANX	Homo sapiens	P27824	Anti Tag CoIP	22314232
Intra	SEC61A1	P61619	CANX	Homo sapiens	P27824	Anti Bait CoIP	22314232

Cross: Cross-species interaction Intra: Intraspecies interaction

SEC61A1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82080	SEC61A Antibody (YA1825)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P87069	SEC61A Antibody (YA6762)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Tubulointerstitial Kidney Disease, Autosomal Dominant, 5	Hyperuricemic Nephropathy, Familial Juvenile, 4 ADTKD5 Hnfj4 Hyperuricemic Nephropathy, Familial Juvenile Type 4 Familial Juvenile Hyperuricemic Nephropathy 4
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Buruli Ulcer	Buruli Ulcer, Susceptibility To Buruli Ulcer Disease Mycobacterium Ulcerans Mycobacterium Ulcerans, Susceptibility To Bairnsdale Ulcer Daintree Ulcer Mossman Ulcer Searl Ulcer Searle'S Ulcer Bud
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Autosomal Dominant Severe Congenital Neutropenia	Severe Congenital Neutropenia Autosomal Dominant Neutropenia, Congenital, Severe, Autosomal Dominant
Tubulointerstitial Kidney Disease, Autosomal Dominant, 1	Familial Juvenile Hyperuricemic Nephropathy Mckd2 Familial Juvenile Hyperuricemic Nephropathy Type 1 Fjhn Medullary Cystic Kidney Disease 2 Uromodulin-Associated Kidney Disease Medullary Cystic Kidney Disease Type 2 ADTKD1 Hnfj1 Glomerulocystic Kidney Disease With Hyperuricemia And Isosthenuria Adtkd-Umod Familial Juvenile Hyperuricemic Nephropathy 1 Umod-Related Adtkd Umod-Related Autosomal Dominant Tubulointerstitial Kidney Disease Hyperuricemic Nephropathy, Familial Juvenile, 1 Gouty Nephropathy, Familial Juvenile Medullary Cystic Kidney Disease 2, Autosomal Dominant Admckd2 Autosomal Dominant Tubulointerstitial Kidney Disease Due To Umod Mutations Adtkd Due To Umod Mutations Autosomal Dominant Tubulointerstitial Kidney Disease, Umod-Related Autosomal Dominant Medullary Cystic Kidney Disease Type 2 Umod-Associated Kidney Disease Uromodulin Kidney Disease Familial Gout-Kidney Disease Familial Gouty Nephropathy Umak Umod-Related Kidney Disease Uromodulin Storage Disease Fjhn1 Gouty Nephropathy Familial Juvenile Nephropathy Familial With Gout Hyperuricemic Nephropathy, Familial Juvenile 1 Hyperuricemic Nephropathy, Familial Juvenile Kidney Disease, Glomerulocystic, With Hyperuricemia And Isosthenuria Nephropathy, Hyperuricemic, Juvenile, Familial, Type 1 Kidney Disease, Cystic, Medullary, Type 2 Medullary Cystic Kidney Disease Type Ii Familial Juvenile Gout
Uterine Corpus Sarcoma	Sarcoma Of Corpus Uteri Sarcoma Of Uterus Sarcoma Of The Corpus Uteri Uterine Sarcoma Sarcoma, Nos Of Uterus
Retinitis Pigmentosa 61	RP61 Retinitis Pigmentosa, Type 61
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139615	Sec61-IN-1	Inhibitor	99.70%	Unkown
HY-RS12621	SEC61A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEC61A1	VGNC	VGNC:49153
Canis familiaris	SEC61A1	VGNC	VGNC:49614
Mus musculus	SEC61A1	MGD	MGI:1858417
Rattus norvegicus	SEC61A1	RGD	RGD:68321
Felis catus	SEC61A1	VGNC	VGNC:64973
Macaca mulatta	SEC61A1	VGNC	VGNC:77265
Others	SEC61A1	NCBI