DNAJB11 - DnaJ heat shock protein family (Hsp40) member B11 Gene

Also Known as DJ9; EDJ; Dj-9; ERj3; PKD6; ABBP2; ERdj3; ERj3p; ABBP-2; UNQ537; PRO1080

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51726

About DNAJB11

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,570,720-186,585,793 (from NCBI)

This gene has 8 transcripts (splice variants), 225 orthologues, 11 paralogues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 37.3), appendix (RPKM 33.9) and 25 other tissues.

Summary

This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 Amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immunoglobulin protein by stimulating ATPase activity. [provided by RefSeq, Mar 2014]

DNAJB11 Products (2)

mRNA	Protein	Name
NM_001378451.1	NP_001365380.1	dnaJ homolog subfamily B member 11 isoform 2 precursor
NM_016306.6	NP_057390.1	dnaJ homolog subfamily B member 11 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables misfolded protein binding	IDA IDA: Inferred from direct assay	28597544	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18923428	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	20335166	GOA
involved in protein maturation	IMP IMP: Inferred from mutant phenotype	29706351	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	20335166	GOA
part of protein folding chaperone complex	IPI IPI: Inferred from physical interaction	28597544	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAJB11 Protein Structure

DnaJ

DnaJ_C

0
100
200
300
358 a.a.

Protein Preferred Names	Protein Names
dnaJ homolog subfamily B member 11	APOBEC1-binding protein 2

DNAJB11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Y2H	20335166
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Anti Tag CoIP	20335166
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Pull Down	20335166
Cross	DNAJB11	Q9UBS4	slrP	Salmonella typhimurium	Q8ZQQ2	Confocal	20335166
Intra	DNAJB11	Q9UBS4	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	33961781
Intra	DNAJB11	Q9UBS4	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	28514442
Intra	DNAJB11	Q9UBS4	HSPA5	Homo sapiens	P11021	Pull Down	20335166
Intra	DNAJB11	Q9UBS4	SIMC1	Homo sapiens	Q8NDZ2	Anti Tag CoIP	33961781
Intra	DNAJB11	Q9UBS4	SIMC1	Homo sapiens	Q8NDZ2	Anti Tag CoIP	28514442
Intra	DNAJB11	Q9UBS4	SIMC1	Homo sapiens	Q8NDZ2	Y2H	21900206
Intra	DNAJB11	Q9UBS4	HTN3	Homo sapiens	P15516	Y2H Array	32296183
Intra	DNAJB11	Q9UBS4	HTN3	Homo sapiens	P15516	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DNAJB11 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810987	DNAJB11 Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Polycystic Kidney Disease 6 With Or Without Polycystic Liver Disease	PKD6
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Congenital Anomalies Of Kidney And Urinary Tract 1	CAKUT1 Renal Hypodysplasia, Nonsyndromic, 1 Rhdns1 Congenital Anomalies Of The Kidney And Urinary Tract 1 Non-Syndromic Renal Hypodysplasia 1 Kidney And Urinary Tract, Anomalies, Congenital, Susceptibility To, Type 1
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Renal-Hepatic-Pancreatic Dysplasia	Ivemark'S Syndrome Ivemark Ii Syndrome Renohepaticopancreatic Dysplasia
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Renal Dysplasia, Cystic	CYSRD Renal Dysplasia, Cystic, Susceptibility To Diffuse Cystic Renal Dysplasia Renal Dysplasia Diffuse Cystic Cystic Renal Dysplasia Susceptibility To Cystic Renal Dysplasia Dysplasia, Renal, Cystic, Susceptibility To Multicystic Dysplastic Kidney
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Short-Rib Thoracic Dysplasia 9 With Or Without Polydactyly	Conorenal Syndrome Saldino-Mainzer Syndrome SRTD9 Mainzer-Saldino Syndrome Mzsds Mainzer-Saldino Disease Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia, And Skeletal Dysplasia Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dysplasia Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dy Mainzer Saldino Syndrome Conorenal Dysplasia Mainzer-Saldino Chondrodysplasia Saldino-Mainzer Dysplasia Short-Rib Thoracic Dysplasia 9 Renal Dysplasia-Retinal Pigmentary Dystrophy-Cerebellar Ataxia-Skeletal Dysplasia Syndrome Mss Renal Dysplasia Retinal Pigmentary Dystrophy Cerebellar Ataxia And Skeletal Dysplasia
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 2 PKD2 Polycystic Kidney Disease, Adult, Type Ii Apkd2 Polycystic Kidney Disease, Type 2 Adpkd2 Adult Polycystic Kidney Disease Type 2 Autosomal Dominant Polycystic Kidney Disease 2 Pkd-2 Polycystic Kidney Disease Adult Type Ii Polycystic Kidney Type 2 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 2
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03864	DNAJB11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DNAJB11	VGNC	VGNC:102690
Rattus norvegicus	DNAJB11	RGD	RGD:1307373
Canis familiaris	DNAJB11	VGNC	VGNC:53459
Mus musculus	DNAJB11	MGD	MGI:1915088
Others	DNAJB11	NCBI