AHA1 Antibody (YA2023)
(Synonyms: AHSA1; C14orf3; HSPC322; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38)AHA1 Antibody (YA2023) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AHA1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IP
IP: Immunoprecipitation
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|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:20-1:50 |
Product Details
AHA1 Antibody (YA2023) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AHA1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38 kDa
Entrez Gene: 10598 Human ; 217737 Mouse ;
SwissProt: O95433 Human ; Q8BK64 Mouse ;
OMIM: 608466 Human
A synthetic peptide of human AHA1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
AHA1 acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins[1][2].
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Subcellular Localization
Cytoplasm, cytosol; Endoplasmic reticulum
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Expression
Tissue_specificity:Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta
Induction:By heat shock and treatment with the HSP90 inhibitor 17-demethoxygeldanamycin (17AAG) -
Isoforms & Post-Translational Modification
O95433 has 2 isomers: O95433-1: 38274 Da (predicted); O95433-2: 32340 Da (predicted).
Phosphorylation at Tyr-223 enhances binding to chaperone HSP90AA1 -
Subunit
Interacts with HSPCA/HSP90 (PubMed:12504007, PubMed:12604615). Interacts (phosphorylated on Tyr-223) with HSP90AA1; the interaction activates HSP90AA1 ATPase activity (PubMed:27353360, PubMed:29127155). Interacts with HSP90AB1 (By similarity). Interacts with GCH1 (PubMed:16696853). Interacts with SRPK1 (PubMed:19240134). Interacts with FLCN (PubMed:27353360)
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SwissProt ID
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Synonyms
AHSA1; C14orf3; HSPC322; Activator of 90 kDa heat shock protein ATPase homolog 1; AHA1; p38
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Research Field
Signal Transduction
Documentation
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