AHSA1 - activator of HSP90 ATPase activity 1 Gene

Also Known as p38; AHA1; hAha1; C14orf3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10598

About AHSA1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:77,457,867-77,469,472 (from NCBI)

This gene has 13 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in testis (RPKM 60.3), adrenal (RPKM 41.8) and 25 other tissues.

Summary

Enables ATPase activator activity; HSP90 protein binding activity; and chaperone binding activity. Involved in positive regulation of ATPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

AHSA1 Products (4)

mRNA	Protein	Name
NM_001321441.2	NP_001308370.1	activator of 90 kDa heat shock protein ATPase homolog 1 isoform 2
NM_012111.3	NP_036243.1	activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1
NM_001321441.2	NP_001308370.1	activator of 90 kDa heat shock protein ATPase homolog 1 isoform 2
NM_012111.3	NP_036243.1	activator of 90 kDa heat shock protein ATPase homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	12504007	GOA
enables Hsp90 protein binding	IPI IPI: Inferred from physical interaction	29127155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12604615	GOA
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	12504007	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	29127155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AHSA1 Protein Structure

Aha1_N

AHSA1

0
100
200
300
338 a.a.

Protein Preferred Names	Protein Names
activator of 90 kDa heat shock protein ATPase homolog 1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1

AHSA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AHSA1	O95433	HSP90AA1	Homo sapiens	P07900	Y2H	12604615
Intra	AHSA1	O95433	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	35271311
Intra	AHSA1	O95433	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	35271311
Intra	AHSA1	O95433	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	AHSA1	O95433	GCH1	Homo sapiens	P30793	Pull Down	16696853

Cross: Cross-species interaction Intra: Intraspecies interaction

AHSA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82278	AHA1 Antibody (YA2023)	WB, IP	Human, Mouse, Rat
HY-P82278A	AHA1 Antibody (YA2023)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Stomatitis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-181478	Hsp90-IN-45	Inhibitor	/	Unkown
HY-RS00485	AHSA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AHSA1	VGNC	VGNC:37730
Felis catus	AHSA1	VGNC	VGNC:59696
Mus musculus	AHSA1	MGD	MGI:2387603
Macaca mulatta	AHSA1	VGNC	VGNC:69601
Rattus norvegicus	AHSA1	RGD	RGD:1589285
Bos taurus	AHSA1	VGNC	VGNC:25755
Others	AHSA1	NCBI