1. MAPK/ERK Pathway
  2. JNK
  3. Ophiopogonin B

Ophiopogonin B 

Cat. No.: HY-N1961
Handling Instructions

Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus.

For research use only. We do not sell to patients.

Ophiopogonin B Chemical Structure

Ophiopogonin B Chemical Structure

CAS No. : 38971-41-4

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Description

Ophiopogonin B induces the autophagy and apoptosis of colon cancer cells by activating JNK/c-Jun signaling pathway. Ophiopogonin B is a saponin compound isolated from Radix Ophiopogonjaponicus[1].

IC50 & Target

JNK

 

In Vitro

Ophiopogonin B (0, 5, 10and 20 μM) suppresses the proliferation of HT-29 and HCT-116 cell lines through the G0/G1 phase cell cycle arrest[1].
Ophiopogonin B induces apoptosis by inhibiting the expression of Bax and cleaved caspase 3 and promoting the expression of Bcl-2. Treatment with Ophiopogonin B also increases the expression of Beclin 1 and the conversion of LC3I to LC3II with the activation of JNK/c-Jun signaling pathway[1].

Molecular Weight

722.90

Formula

C₃₉H₆₂O₁₂

CAS No.

38971-41-4

SMILES
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Keywords:

Ophiopogonin BJNKc-Jun N-terminal kinaseAutophagyapoptosiscoloncancersaponinRadixOphiopogonjaponicusInhibitorinhibitorinhibit

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Ophiopogonin B
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