Parbendazole-d3
Parbendazole-d3 (SKF 2904-d3) is the deuterated-labeled Parbendazole (HY-115364). Parbendazole (SKF‑29044) is an orally active benzimidazole carbamate compound with multiple biological activities. Parbendazole binds to free tubulin and inhibits microtubule polymerization; it also activates the JNK/c‑Jun signaling axis and upregulates the expression of the downstream axonal repulsion factor Sema3A. Parbendazole upregulates KAL-1 mRNA expression, reduces nerve growth factor levels, and promotes the terminal differentiation of normal human epidermal keratinocytes. Parbendazole induces apoptosis in differentiated acute myeloid leukemia monocytes and exerts antileukemic activity in a mouse xenograft model of acute myeloid leukemia. Parbendazole exhibits broad-spectrum anthelmintic activity against various animal nematodes. Parbendazole is used in research related to acute myeloid leukemia and parasitic infections.
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- No. CAS: 1613439-58-9
- Fòrmula: C13H14D3N3O2
- Peso molecular:250.31
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
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JNK |
β-Tubulin |
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1613439-58-9
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Unlabeled CAS 14255-87-9
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Peso molecular 250.31
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Fòrmula C13H14D3N3O2
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SMILES
[2H]C([2H])([2H])OC(NC1=NC2=CC(CCCC)=CC=C2N1)=O
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Synonyms
SKF 2904-d3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Matsuo H, et al. Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Communications biology. 2024 Jan 24;7(1):123. [Content Brief]
[3]. Foster KE, et al. A mutant beta-tubulin confers resistance to the action of benzimidazole-carbamate microtubule inhibitors both in vivo and in vitro. European journal of biochemistry. 1987 Mar 16;163(3):449-55. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Parbendazole-d3 Related Classifications
HY-115364S Related Classifications
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