APLP2 - amyloid beta precursor like protein 2 Gene

Also Known as APPH; APPL2; CDEBP; APLP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 334

About APLP2

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:130,069,894-130,144,805 (from NCBI)

This gene has 26 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 347.8), lung (RPKM 236.7) and 24 other tissues.

Summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

APLP2 Products (30)

mRNA Protein Name
NM_001142276.2 NP_001135748.1 amyloid beta precursor like protein 2 isoform 2 precursor
NM_001142277.2 NP_001135749.1 amyloid beta precursor like protein 2 isoform 3
NM_001142278.2 NP_001135750.1 amyloid beta precursor like protein 2 isoform 4 precursor
NM_001243299.2 NP_001230228.1 amyloid beta precursor like protein 2 isoform 5
NM_001328682.2 NP_001315611.1 amyloid beta precursor like protein 2 isoform 6 precursor
NM_001328684.2 NP_001315613.1 amyloid beta precursor like protein 2 isoform 7 precursor
NM_001328685.2 NP_001315614.1 amyloid beta precursor like protein 2 isoform 8 precursor
NM_001328686.2 NP_001315615.1 amyloid beta precursor like protein 2 isoform 9 precursor
NM_001382526.1 NP_001369455.1 amyloid beta precursor like protein 2 isoform 10 precursor
NM_001382527.1 NP_001369456.1 amyloid beta precursor like protein 2 isoform 11 precursor
NM_001382528.1 NP_001369457.1 amyloid beta precursor like protein 2 isoform 12
NM_001382529.1 NP_001369458.1 amyloid beta precursor like protein 2 isoform 13 precursor
NM_001382530.1 NP_001369459.1 amyloid beta precursor like protein 2 isoform 14
NM_001382531.1 NP_001369460.1 amyloid beta precursor like protein 2 isoform 15
NM_001382532.1 NP_001369461.1 amyloid beta precursor like protein 2 isoform 16
NM_001382533.1 NP_001369462.1 amyloid beta precursor like protein 2 isoform 17
NM_001382534.1 NP_001369463.1 amyloid beta precursor like protein 2 isoform 18
NM_001382535.1 NP_001369464.1 amyloid beta precursor like protein 2 isoform 19
NM_001382536.1 NP_001369465.1 amyloid beta precursor like protein 2 isoform 20
NM_001382537.1 NP_001369466.1 amyloid beta precursor like protein 2 isoform 21
NM_001382538.1 NP_001369467.1 amyloid beta precursor like protein 2 isoform 22 precursor
NM_001382539.1 NP_001369468.1 amyloid beta precursor like protein 2 isoform 23
NM_001382540.1 NP_001369469.1 amyloid beta precursor like protein 2 isoform 24
NM_001382541.1 NP_001369470.1 amyloid beta precursor like protein 2 isoform 25
NM_001382542.1 NP_001369471.1 amyloid beta precursor like protein 2 isoform 26
NM_001382543.1 NP_001369472.1 amyloid beta precursor like protein 2 isoform 27
NM_001382544.1 NP_001369473.1 amyloid beta precursor like protein 2 isoform 28
NM_001382545.1 NP_001369474.1 amyloid beta precursor like protein 2 isoform 29
NM_001382546.1 NP_001369475.1 amyloid beta precursor like protein 2 isoform 30 precursor
NM_001642.3 NP_001633.1 amyloid beta precursor like protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16193067 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8855266 GOA
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
25301953 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
7702756 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APLP2 Protein Structure

APP_N

APP_N: Amyloid A4 N-terminal heparin-binding (49 - 147)

APP_Cu_bd

APP_Cu_bd: Copper-binding of amyloid precursor, CuBD (148 - 205)

Kunitz_BPTI

Kunitz_BPTI: Kunitz/Bovine pancreatic trypsin inhibitor domain (309 - 361)

APP_E2

APP_E2: E2 domain of amyloid precursor protein (365 - 548)

APP_amyloid

APP_amyloid: beta-amyloid precursor protein C-terminus (708 - 759)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
Protein Preferred Names Protein Names

amyloid beta precursor like protein 2

  • CDEI box-binding protein

APLP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
APLP2 Q06481 DEDD Homo sapiens O75618
Display Tech
20195357
Intra
APLP2 Q06481 DEDD Homo sapiens O75618
TAP
20195357
Intra
APLP2 Q06481 APBB3 Homo sapiens O95704
Y2H
9461550
Intra
APLP2 Q06481 ITM2B Homo sapiens Q9Y287
Anti Bait CoIP
34446781
Intra
APLP2 Q06481 APP Homo sapiens P05067-4
Anti Tag CoIP
16193067
Intra
APLP2 Q06481 MED12 Homo sapiens Q93074
Pull Down
21293490
Intra
APLP2 Q06481 APLP1 Homo sapiens P51693
Anti Tag CoIP
16193067
Intra
APLP2 Q06481 APBB2 Homo sapiens Q92870
Anti Bait CoIP
8855266
Intra
APLP2 Q06481 JUN Homo sapiens P05412
Display Tech
20195357
Intra
APLP2 Q06481 APLP2 Homo sapiens Q06481
Anti Tag CoIP
16193067
Intra
APLP2 Q06481 APBB1 Homo sapiens O00213
Y2H
9461550
Intra
APLP2 Q06481 APLP2 Homo sapiens Q06481
Anti Bait CoIP
16193067
Intra
APLP2 Q06481 ETS1 Homo sapiens P14921
Display Tech
20195357
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant APLP2 Proteins

Cat. No. Product Name Accession Purity
HY-P700659 APLP-2 Protein, Human (HEK293, His) Q06481-1 (G32-S692) ≥ 95%, as determined by reducing SDS-PAGE.

APLP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82977 APLP2 Antibody (YA2722) WB Human, Rat
HY-P82977A APLP2 Antibody (YA2722)(PBS only) WB Human, Rat

Related Diseases

Diseases Alias
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00827 APLP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20854 Aplp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27369 Aplp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris APLP2 VGNC VGNC:37989
Felis catus APLP2 VGNC VGNC:67762
Rattus norvegicus APLP2 RGD RGD:2128
Mus musculus APLP2 MGD MGI:88047
Bos taurus APLP2 VGNC VGNC:26020
Macaca mulatta APLP2 VGNC VGNC:69984
Others APLP2 NCBI