APLP2 Antibody (YA2722)
(Synonyms: APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP)APLP2 Antibody (YA2722) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APLP2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
APLP2 Antibody (YA2722) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APLP2.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 115 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 87 kDa
Entrez Gene: 334 Human ; 11804 Mouse ;
SwissProt: Q06481 Human ; Q06335 Mouse ; P15943 Rat
OMIM: 104776 Human
A synthetic peptide of human APLP2
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
APLP2 may play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Nucleus
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Expression
Tissue_specificity:Expressed in placenta, brain, heart, lung, liver, kidney and endothelial tissues -
Isoforms & Post-Translational Modification
Q06481 has 6 isomers: Q06481-1: 86956 Da (predicted); Q06481-2: 80721 Da (predicted); Q06481-3: 85487 Da (predicted); Q06481-4: 79238 Da (predicted); Q06481-5: 59151 Da (predicted); Q06481-6: 87215 Da (predicted).
The BPTI/Kunitz inhibitor domain is O-glycosylated -
Subunit
Interacts with CPEB1. Interacts (via NPXY motif) with DAB2 (via PID domain); the interaction is impaired by tyrosine phosphorylation of the NPXY motif (By similarity). Interacts (via cytoplasmic domain) with APBB2/FE65L (PubMed:8855266). Interacts (via intracellular domain) with APBB3/FE65L2 (PubMed:10081969)
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SwissProt ID
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Synonyms
APLP2; APPL2; Amyloid-like protein 2; APLP-2; APPH; Amyloid protein homolog; CDEI box-binding protein; CDEBP
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Research Field
Neuroscience
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