DEDD - death effector domain containing Gene

Homo sapiens

Also known as DEFT; KE05; DEDD1; FLDED1; CASP8IP1

Gene ID: 9191 | Gene type: protein coding

About DEDD

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,120,974-161,132,667 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 12.8), placenta (RPKM 9.3) and 25 other tissues.

Summary

This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak Apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

DEDD Products(4)

mRNA	Protein	Name
NM_001039711.2	NP_001034800.1	death effector domain-containing protein isoform b
NM_001039712.2	NP_001034801.1	death effector domain-containing protein isoform b
NM_001330765.2	NP_001317694.1	death effector domain-containing protein isoform a
NM_032998.3	NP_127491.1	death effector domain-containing protein isoform b

DEDD Protein Structure

DED

0
100
200
300
318 a.a.

Protein Preferred Names

Protein Names

death effector domain-containing protein

DEDPro1

Related Diseases

Diseases

Alias

Arthrogryposis, Distal, Type 10

DA10	Distal Arthrogryposis Type 10
Short Achilles Tendon	Plantar Flexion Contracture
Short Tendo Calcaneus	Congenital Plantar Contractures
Tendo Calcaneus, Short

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03669	DEDD Human Pre-designed siRNA Set A		/	Unkown
HY-RS03670	DEDD2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DEDD	VGNC	VGNC:71768
Mus musculus	DEDD	MGD	MGI:1333874
Rattus norvegicus	DEDD	RGD	RGD:620050
Bos taurus	DEDD	VGNC	VGNC:27984
Canis familiaris	DEDD	VGNC	VGNC:39872

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