APBB3 - amyloid beta precursor protein binding family B member 3 Gene

Also Known as SRA; FE65L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10307

Summary

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's Disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Ubiquitous expression in testis (RPKM 17.3), adrenal (RPKM 13.2) and 25 other tissues.

APBB3 Products (4)

mRNA Protein Name
NM_006051.4 NP_006042.3 amyloid-beta A4 precursor protein-binding family B member 3 isoform d
NM_133172.3 NP_573418.2 amyloid-beta A4 precursor protein-binding family B member 3 isoform c
NM_133173.3 NP_573419.2 amyloid-beta A4 precursor protein-binding family B member 3 isoform b
NM_133174.3 NP_573420.2 amyloid-beta A4 precursor protein-binding family B member 3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
12153398 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9461550 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of protein secretion IDA
IDA: Inferred from direct assay
12153398 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytosol IDA
IDA: Inferred from direct assay
12153398 GOA
located in membrane IDA
IDA: Inferred from direct assay
12153398 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12153398 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APBB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
APBB3 O95704 EGFR Homo sapiens P00533
Protein Array
16273093
Intra
APBB3 O95704 DAPP1 Homo sapiens Q9UN19
Lumier
25814554
Intra
APBB3 O95704 APP Homo sapiens P05067
Validated Y2H
32814053
Intra
APBB3 O95704 APP Homo sapiens P05067
Y2H Pooling
32814053
Intra
APBB3 O95704 APP Homo sapiens P05067
Y2H Array
32814053
Intra
APBB3 O95704 APP Homo sapiens P05067
Anti Tag CoIP
33961781
Intra
APBB3 O95704 APP Homo sapiens P05067
Y2H
9461550
Intra
APBB3 O95704 APLP2 Homo sapiens Q06481
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction