ICA-1S
ICA-1S is a specific PKC-ι inhibitor. ICA-1S can inhibit MAPK/JNK signaling pathway and downregulate the levels of c-Jun and TNF-α. ICA-1S inhibits the proliferation of breast cancer cells. ICA-1S induces apoptosis of breast cancer cells. ICA-1S can be used in breast cancer-related research.
For research use only. We do not sell to patients.
- CAS No.: 90597-15-2
- Formula: C10H16N4O4
- Molecular Weight:256.26
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Caspase Isoforms
More
Biological Activity
ICA-1S (2.5-30 μM; 120 h) potently inhibits the proliferation of BT-549 and MCF-7 breast cancer cells, with IC50 values of 10 μM and 20 μM respectively after 5 days of treatment[1].
Treatment with ICA-1S (10-20 μM; 120 h) at the IC50 concentration for 5 days induces apoptosis in BT-549 (via upregulation of cleaved Caspase 3 and cleaved PARP) and MCF-7 (via upregulation of cleaved PARP) breast cancer cells[1].
ICA-1S (10-20 μM (MCF-7); 120 h) downregulates the levels of PKC-ι and PKC-ζ in BT-549 and MCF-7 breast cancer cells, but exerts no such effect on MCF-7 cells[1].
ICA-1S (10-20 μM; 120 h) inhibits the oncogenic MAPK/JNK pathway and reduces the levels of phosphorylated and total pathway proteins, c-Jun, and TNF-α in BT-549 and MCF-7 breast cancer cells[1].
ICA-1S (10-20 μM; 120 h) reduces c-Jun mRNA levels by 50% in BT-549 breast cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BT-549, MCF-7 breast cancer cell lines
-
Concentration:2.5 μM, 5 μM, 10 μM, 20 μM, 30 μM
-
Incubation Time:120 h, with treatments every 24 h
-
Result:Significantly reduced cell proliferation in both cell lines.
Achieved an IC50 of 10 μM, resulting in 45% inhibition for BT-549 cells.
Achieved an IC50 of 20 μM, resulting in 43% inhibition for MCF-7 cells.
-
Cell Line:BT-549, MCF-7 breast cancer cell lines
-
Concentration:10 μM (BT-549); 20 μM (MCF-7)
-
Incubation Time:120 h
-
Result:Reduced c-Jun mRNA levels by 50% in BT-549 cells compared to untreated controls.
Had no significant effect on c-Jun mRNA levels in MCF-7 cells.
Chemical Information
-
CAS No. 90597-15-2
-
Molecular Weight 256.26
-
Formula C10H16N4O4
-
SMILES
O[C@H]1[C@H](N2C(N)=C(N=C2)C(N)=O)C[C@@H]([C@H]1O)CO
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz