ICA-1S 

ICA-1S is a specific PKC-ι inhibitor. ICA-1S can inhibit MAPK/JNK signaling pathway and downregulate the levels of c-Jun and TNF-α. ICA-1S inhibits the proliferation of breast cancer cells. ICA-1S induces apoptosis of breast cancer cells. ICA-1S can be used in breast cancer-related research^[1].

ICA-1S (2.5-30 μM; 120 h) potently inhibits the proliferation of BT-549 and MCF-7 breast cancer cells, with IC₅₀ values of 10 μM and 20 μM respectively after 5 days of treatment^[1].
Treatment with ICA-1S (10-20 μM; 120 h) at the IC₅₀ concentration for 5 days induces apoptosis in BT-549 (via upregulation of cleaved Caspase 3 and cleaved PARP) and MCF-7 (via upregulation of cleaved PARP) breast cancer cells^[1].
ICA-1S (10-20 μM (MCF-7); 120 h) downregulates the levels of PKC-ι and PKC-ζ in BT-549 and MCF-7 breast cancer cells, but exerts no such effect on MCF-7 cells^[1].
ICA-1S (10-20 μM; 120 h) inhibits the oncogenic MAPK/JNK pathway and reduces the levels of phosphorylated and total pathway proteins, c-Jun, and TNF-α in BT-549 and MCF-7 breast cancer cells^[1].
ICA-1S (10-20 μM; 120 h) reduces c-Jun mRNA levels by 50% in BT-549 breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

240.26

C₁₀H₁₆N₄O₃

O=C(C1=C(N)N([C@H]2[C@H](O)[C@@H](O)[C@H](C)C2)C=N1)N

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Nowshin Oishee N, et al. PKC-ι Regulates an Oncogenic Positive Feedback Loop Between the MAPK/JNK Signaling Pathway, c-Jun/AP-1 and TNF-α in Breast Cancer. Int J Mol Sci. 2025;26(15):7288. Published 2025 Jul 28.