1. Apoptosis
  2. Apoptosis
  3. Methyl protodioscin

Methyl protodioscin (Synonyms: NSC-698790; Smilax saponin B)

Cat. No.: HY-N0863 Purity: ≥98.0%
Handling Instructions

Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.

For research use only. We do not sell to patients.

Methyl protodioscin Chemical Structure

Methyl protodioscin Chemical Structure

CAS No. : 54522-52-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 468 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 468 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2050 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest. IC50 value: Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2].

Molecular Weight

1063.23

Formula

C₅₂H₈₆O₂₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 140 mg/mL (131.67 mM; Need ultrasonic)

H2O : 25 mg/mL (23.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9405 mL 4.7027 mL 9.4053 mL
5 mM 0.1881 mL 0.9405 mL 1.8811 mL
10 mM 0.0941 mL 0.4703 mL 0.9405 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.5 mg/mL (3.29 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 3.5 mg/mL (3.29 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.5 mg/mL (3.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Methyl protodioscin
Cat. No.:
HY-N0863
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