1. Apoptosis
  2. Apoptosis
  3. Methyl protodioscin

Methyl protodioscin (Synonyms: NSC-698790; Smilax saponin B)

Cat. No.: HY-N0863 Purity: >98.0%
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Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest.

For research use only. We do not sell to patients.

Methyl protodioscin Chemical Structure

Methyl protodioscin Chemical Structure

CAS No. : 54522-52-0

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10 mM * 1 mL in DMSO USD 561 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
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Description

Methyl protodioscin(NSC-698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest. IC50 value: Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose- and time-dependent manner. The significant G2/M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD-induced apoptosis was accompanied by a significant reduction of mitochondrial membrane potential, release of mitochondrial cytochrome c to cytosol, activation of caspase-3, downregulation of Bcl-2, p-Bad, and upregulation of Bax [1]. In THP-1 macrophages, MPD increases levels of ABCA1 mRNA and protein in dose- and time-dependent manners, and apoA-1-mediated cholesterol efflux. MPD also decreases the gene expressions of HMGCR, FAS and ACC for cholesterol and fatty acid synthesis [2].

Molecular Weight

1063.23

Formula

C₅₂H₈₆O₂₂

CAS No.

54522-52-0

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

Methyl protodioscinNSC-698790Smilax saponin BNSC698790NSC 698790ApoptosisInhibitorinhibitorinhibit

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