JNK3 inhibitor-9
JNK3 inhibitor-9 (Compound 24a) is a potent, selective and BBB-permeable JNK3 inhibitor with an IC50 value of 12 nM. JNK3 inhibitor-9 also potently inhibits GSK3α/β (IC50s: 14 and 35 nM, respectively) involved in Tau phosphorylation. JNK3 inhibitor-9 reduces c-Jun and APP phosphorylation. JNK3 inhibitor-9 protects neurons from Aβ1-42 toxicity.
For research use only. We do not sell to patients.
- Formula: C25H27N7O2
- Molecular Weight:457.53
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
JNK3 12 nM (IC50) |
GSK3α 14 nM (IC50) |
GSK3β 35 nM (IC50) |
Chemical Information
-
Molecular Weight 457.53
-
Formula C25H27N7O2
-
SMILES
O=C(N)C1=NN(C2=NC(N[C@H]3CN(C(C4CC4)=O)CCC3)=NC=C2)C=C1/C=C/C5=CC=CC=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JNK3 inhibitor-9 Related Classifications
HY-168859 Related Classifications
Powered by Bioz