STRN4 - striatin 4 Gene

Also Known as ZIN; PPP2R6C; zinedin

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29888

About STRN4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,719,511-46,746,450 (from NCBI)

This gene has 24 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in testis (RPKM 42.4), spleen (RPKM 16.0) and 25 other tissues.

Summary

Enables armadillo repeat domain binding activity and protein Phosphatase 2A binding activity. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]

STRN4 Products (2)

mRNA	Protein	Name
NM_001039877.2	NP_001034966.1	striatin-4 isoform 2
NM_013403.3	NP_037535.2	striatin-4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables armadillo repeat domain binding	IPI IPI: Inferred from physical interaction	18502210	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	18782753	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18782753	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	32640226	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	32640226	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STRN4 Protein Structure

Striatin

WD40

0
200
400
600
753 a.a.

Protein Preferred Names	Protein Names
striatin-4	protein phosphatase 2 regulatory subunit B'''gamma

STRN4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STRN4	Q9NRL3	JUN	Homo sapiens	P05412	TAP	20195357

Cross: Cross-species interaction Intra: Intraspecies interaction

STRN4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82343	Striatin 4 Antibody (YA2088)	WB, ICC/IF, IP	Human
HY-P82343A	Striatin 4 Antibody (YA2088)(PBS only)	WB, ICC/IF, IP	Human

Related Diseases

Diseases	Alias
Muscular Dystrophy-Dystroglycanopathy , Type C, 5	Lgmd2i Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2i MDDGC5 Limb-Girdle Muscular Dystrophy Due To Fkrp Deficiency Limb-Girdle Muscular Dystrophy Type 2i Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 9 Lgmdr9 Muscular Dystrophy, Limb-Girdle, Type 2i Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Frkp-Related Fkrp-Related Limb-Girdle Muscular Dystrophy R9 Fkrp-Related Lgmd R9 Lgmd Due To Fkrp Deficiency Lgmd Type 2i Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Frkp-Related Muscular Dystrophy Limb-Girdle Type 2i Muscular Dystrophy-Dystroglycanopathy Type C 5 Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C5 Dystrophy, Muscular, Limb-Girdle, Type 2i
Cerebral Cavernous Malformations 3	Cerebral Cavernous Malformation 3 CCM3 Cerebral Cavernous Malformations-3 Cavernous Angiomatous Malformations Cavernous Hemangioma Of The Brain Cerebral Capillary Malformations Cerebral Cavernoma Familial Cavernous Angioma Cerebral Cavernous Malformations, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13968	STRN4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STRN4	VGNC	VGNC:46947
Felis catus	STRN4	VGNC	VGNC:65803
Bos taurus	STRN4	VGNC	VGNC:35426
Rattus norvegicus	STRN4	RGD	RGD:1307030
Macaca mulatta	STRN4	VGNC	VGNC:78128
Mus musculus	STRN4	MGD	MGI:2142346
Others	STRN4	NCBI