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Cat. No.: HY-181662

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DLK-IN-2

DLK-IN-2 is a selective inhibitor of DLK and neuroprotective agent. DLK-IN-2 shows no significant inhibition against CYPs 3A4, 2D6 and 2C9. DLK-IN-2 inhibits acute axonal palmitoylation of DLK, blocks DLK-dependent pro-degenerative axon-to-soma retrograde signaling and suppresses c-Jun phosphorylation. DLK-IN-2 can be used for the mechanistic study of neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 883012-32-6
Formula: C₂₃H₂₅ClN₂O₃S
Molecular Weight:444.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

DLK-IN-2 Chemical Structure

CAS No.: 883012-32-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

MAP3K12/DLK

All MAP3K Isoforms :

In Vitro

DLK-IN-2 (compound 13) (10 μM; 1 h pre-incubation, 2.5 h post-deprivation) significantly inhibits trophic factor deprivation-induced c-Jun phosphorylation in primary embryonic day 16 rat DRG neurons^[1].
DLK-IN-2 (10 μM; 1 h pre-incubation, 45 h post-deprivation) significantly protects primary embryonic day 16 rat DRG neurons from trophic factor deprivation-induced neurodegeneration^[1].
DLK-IN-2 (10 μM; 4 h post-injury) transiently reduces acute axotomy-induced Wallerian degeneration in primary embryonic day 16 rat DRG neuron spot cultures, but does not protect axons at 6 h post-injury^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Embryonic rat DRG neurons
Concentration:

10 μM
Incubation Time:

2.5 h (p-c-Jun); 4 h (NMNAT2, STMN2)
Result:

Significantly reduced TD-induced c-Jun phosphorylation; did not stabilize NMNAT2 or STMN2.

Chemical Information

CAS No. 883012-32-6
Molecular Weight 444.97
Formula C₂₃H₂₅ClN₂O₃S
SMILES

O=S(C1=CC=C(NC(C2=CC=C(Cl)C=C2)=O)C=C1)(NC34CC5CC(C4)CC(C5)C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang X, et al. Combinatorial chemistry identifies additional compounds that selectively inhibit DLK-dependent retrograde signaling while minimally affecting other axonal roles of DLK. Sci Rep. 2026;16(1):3892. Published 2026 Jan 27. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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DLK-IN-2

All MAP3K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DLK-IN-2 Related Classifications

HY-181662 Related Classifications